Investigating the Association Between Verbal Forgetting and Pathological Markers of Alzheimer’s and Lewy Body Diseases
| Autor: | Alzheimer’s Disease Neuroimaging Initiative, Morgan J Schaeffer, Brandy L. Callahan |
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| Rok vydání: | 2019 |
| Předmět: |
Lewy Body Disease
Male 0301 basic medicine medicine.medical_specialty Neuroimaging tau Proteins Autopsy Neuropathology Hippocampus Memory and Learning Tests Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Internal medicine mental disorders medicine Humans Pathological Aged Amyloid beta-Peptides Lewy body Dementia with Lewy bodies business.industry General Neuroscience Putamen Reproducibility of Results General Medicine Verbal Learning medicine.disease Psychiatry and Mental health Clinical Psychology 030104 developmental biology alpha-Synuclein Biomarker (medicine) Female Atrophy Geriatrics and Gerontology business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 70:877-887 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-180962 |
| Popis: | BACKGROUND The percentage of verbal forgetting (VF%) measure of the Rey Auditory Verbal Learning Test (RAVLT) has been proposed to differentiate patients diagnosed clinically with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). OBJECTIVE To determine if VF% aligns with gold-standard biomarker and autopsy evidence of AD and DLB neuropathology. METHODS Clinical, cognitive, sociodemographic, and biomarker data were collected from 315 patients with baseline cognitive impairment and 485 normal controls from the Alzheimer's Disease Neuroimaging Initiative (ADNI). AD markers included reduced cerebrospinal fluid (CSF) amyloid-β, elevated total-tau and phosphorylated-tau, hippocampal atrophy, and the presence of amyloid plaques and neurofibrillary tangles at autopsy. DLB markers included reduced CSF α-synuclein, preserved hippocampus, atrophied putamen, occipital glucose metabolism, and the presence of Lewy bodies at autopsy. Cognitively impaired participants were classified as ADVF% (n = 190) or DLBVF% (n = 125) based on their RAVLT VF% scores using a 75% cut-off (≥75% = ADVF% |
| Databáze: | OpenAIRE |
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