Pregnancy outcomes associated with viral hepatitis
| Autor: | Mihir Gandhi, Geeta K. Swamy, K. Reddick, Andra H. James, Ravi Jhaveri |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty medicine.disease_cause Pre-Eclampsia Pregnancy Risk Factors Virology Humans Medicine reproductive and urinary physiology Hepatitis B virus Hepatitis Cholestasis Fetal Growth Retardation Hepatology Cesarean Section business.industry Obstetrics Antepartum haemorrhage Infant Newborn Pregnancy Outcome virus diseases Hepatitis C Hepatitis B medicine.disease digestive system diseases female genital diseases and pregnancy complications Pregnancy Complications Gestational diabetes Diabetes Gestational Infectious Diseases Premature Birth Female business Viral hepatitis |
| Zdroj: | Journal of Viral Hepatitis. 18 |
| ISSN: | 1365-2893 1352-0504 |
| DOI: | 10.1111/j.1365-2893.2011.01436.x |
| Popis: | Summary. The aim of this study was to examine the contribution of hepatitis B virus (HBV) and hepatitis C virus (HCV) to pregnancy-related complications including gestational diabetes mellitus (GDM), preterm birth (PTB), intrauterine growth restriction (IUGR), pre-eclampsia, antepartum haemorrhage and cholestasis. The Nationwide Inpatient Sample was queried for all pregnancy-related discharges, pregnancy complications and viral hepatitis from 1995 to 2005. Logistic regression was used to examine the association between HBV, HCV, HBV + HCV and pregnancy-related complications including GDM, PTB, IUGR, pre-eclampsia, antepartum haemorrhage, cholestasis and caesarean delivery. Model covariates included maternal age, race, insurance status, substance use and medical complications including liver complication, hypertension, HIV, anaemia, thrombocytopenia and sexually transmitted infections. Of 297 664 pregnant women data available for analysis, 1446 had a coded diagnosis of HBV, HCV or both. High-risk behaviours, such as smoking, alcohol and substance use were higher in women with either HBV or HCV. Women with HBV had an increased risk for PTB (aOR 1.65, CI [1.3, 2.0]) but a decreased risk for caesarean delivery (aOR 0.686, CI [0.53, 0.88]). Individuals with HCV had an increased risk for GDM (aOR 1.6, CI [1.0, 2.6]). Individuals with both HBV and HCV co-infection had an increased risk for antepartum haemorrhage (aOR 2.82, CI [1.1, 7.2]). There was no association of viral hepatitis with IUGR or pre-eclampsia. Women with hepatitis have an increased risk for complications during pregnancy. Research to determine the efficacy and cost-effectiveness of counselling patients about potential risks for adverse outcomes is warranted. |
| Databáze: | OpenAIRE |
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