Highly aligned and interconnected porous poly(ε-caprolactone) scaffolds derived from co-continuous polymer blends
| Autor: | Baisong Zhao, Ji-Hua Li, Xiang Li, Zhong-Ming Li, Hua-Mo Yin, Jia-Zhuang Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
02 engineering and technology macromolecular substances 010402 general chemistry 01 natural sciences chemistry.chemical_compound Phase (matter) lcsh:TA401-492 General Materials Science Composite material Porosity Mechanical Engineering Isotropy technology industry and agriculture 021001 nanoscience & nanotechnology equipment and supplies 0104 chemical sciences chemistry Mechanics of Materials Melting point Extrusion lcsh:Materials of engineering and construction. Mechanics of materials Polymer blend Elongation 0210 nano-technology Caprolactone |
| Zdroj: | Materials & Design, Vol 128, Iss, Pp 112-118 (2017) |
| ISSN: | 0264-1275 |
| Popis: | Constructing oriented porous architecture in the scaffolds offers the basis for mimicking the structure of highly organized tissues. In the current work, we attempted to fabricate three-dimensional (3D), oriented porous poly(ε-caprolactone) (PCL) scaffolds by water extracting polyethylene oxide (PEO) from the oriented PCL/PEO co-continuous blends. Solid phase extrusion was imposed to the bulk co-continuous blends so as to align both PCL and PEO phases along the extrusion direction, where coarsening of binary blends was impeded due to control over the extrusion temperature below their melting points. Thus, fully interconnected (connectivity: ~100%) aligned pores with uniform size were generated in the PCL porous scaffold after PEO extraction. Intriguingly, in vitro bone marrow stem cell staining results showed that such a porous scaffold with anisotropic structure exhibited very high ability to guide cellular alignment and elongation compared to the regular one with isotropic structure. The enabling strategy provides a versatile, scalable and tissue-friendly route to construct the 3D porous scaffolds with highly interconnected aligned pores, which is promising for the use in tissue repair. Keywords: Oriented porous architecture, Co-continuous blend, Solid phase extrusion, Cellular alignment |
| Databáze: | OpenAIRE |
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