Multitasking by Polycomb response elements
| Autor: | Sharmistha Kundu, Robert E. Kingston, Elizabeth S. Jaensch |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
animal structures Polycomb-Group Proteins Locus (genetics) macromolecular substances Computational biology Cell lineage Biology Response Elements ENCODE 03 medical and health sciences chemistry.chemical_compound Genetics Animals Drosophila Proteins Gene silencing Human multitasking Enhancer Regulator gene Polycomb Repressive Complex 1 fungi DNA-Binding Proteins Drosophila melanogaster 030104 developmental biology chemistry Perspective DNA Developmental Biology |
| Zdroj: | Genes & Development. 31:1069-1072 |
| ISSN: | 1549-5477 0890-9369 |
| Popis: | Development requires the expression of master regulatory genes necessary to specify a cell lineage. Equally significant is the stable and heritable silencing of master regulators that would specify alternative lineages. This regulated gene silencing is carried out by Polycomb group (PcG) proteins, which must be correctly recruited only to the subset of their target loci that requires lineage-specific silencing. A recent study by Erceg and colleagues (pp. 590–602) expands on a key aspect of that targeting: The same DNA elements that recruit PcG complexes to a repressed locus also encode transcriptional enhancers that function in different lineages where that locus must be expressed. Thus, PcG targeting elements overlap with enhancers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|