Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials
| Autor: | Lawrence Scahill, Christopher J. McDougle, Yanhong Deng, James T. McCracken, Benedetto Vitiello, L. Eugene Arnold, Michael G. Aman, Elaine Tierney, James Dziura, Victoria Hallett |
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| Rok vydání: | 2012 |
| Předmět: |
Research design
medicine.medical_specialty Aberrant Behavior Checklist Child Development Disorders Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Adolescent Autism Placebo Article law.invention Double-Blind Method Randomized controlled trial law Developmental and Educational Psychology medicine Humans Child Preschool Social Behavior Psychiatry Pervasive Social withdrawal Psychiatric Status Rating Scales Risperidone Social perception Social disability Antipsychotic Agents Child Development Disorders Pervasive Child Preschool Research Design Treatment Outcome Social Perception medicine.disease Autism spectrum disorder Parent training Psychology Clinical psychology medicine.drug |
| Zdroj: | Journal of Autism and Developmental Disorders. 43:739-746 |
| ISSN: | 1573-3432 0162-3257 |
| DOI: | 10.1007/s10803-012-1689-3 |
| Popis: | There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials. |
| Databáze: | OpenAIRE |
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