Sperm stimulants can improve fertilization rates in male-factor cases undergoing IVF to the same extent as micromanipulation by partial zona dissection (PZD) or subzonal sperm insemination (SUZI): A randomized controlled study
| Autor: | Barbara Bootsma, W. Rohini Edirisinghe, John L. Yovich, Jeanne M. Yovich, S.M. Junk |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Pregnancy Rate Phosphodiesterase Inhibitors medicine.medical_treatment Zona Semen Fertilization in Vitro Biology Insemination Andrology Human fertilization Pregnancy Genetics medicine Humans Pentoxifylline Infertility Male Insemination Artificial Zona Pellucida Genetics (clinical) In vitro fertilisation Deoxyadenosines Artificial insemination Obstetrics and Gynecology General Medicine biology.organism_classification Spermatozoa Sperm Surgery Dissection Reproductive Medicine Sperm Motility Female Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics. 12:312-318 |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/bf02213710 |
| Popis: | Our purpose was to evaluate the efficacy of direct insemination (IVF), micromanipulation by partial zona dissection (PZD), and subzonal sperm insemination (SUZI) using sperm-treated with pentoxifylline (PF) +/- 2-deoxyadenosine (2DA).The overall fertilization rate achieved was similar for all three fertilization techniques (33.1, 30.2, and 26.9% for IVF, SUZI, and PZD, respectively). Patients who had reduced fertilization in previous IVF attempts showed improved fertilization with sperm stimulants, either PF alone or PF in combination with 2DA in standard IVF. In certain cases, SUZI or PZD gave significantly improved fertilization rates in comparison to IVF.Selective use of sperm stimulants in IVF can achieve fertilization for the majority of male-factor cases. However, PZD and SUZI techniques are useful, especially when sperm stimulants fail to achieve fertilization or achieve poor fertilization in direct insemination. |
| Databáze: | OpenAIRE |
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