Impaired lipid accumulation in the liver of Tsc2-heterozygous mice during liver regeneration
| Autor: | Raymond S. Yeung, Yoko Obayashi, Nelson Fausto, Jean S. Campbell |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
MAPK/ERK pathway Heterozygote medicine.medical_specialty Time Factors medicine.medical_treatment Biophysics mTORC1 Biology Biochemistry Mice Internal medicine Tuberous Sclerosis Complex 2 Protein medicine Animals Hepatectomy Phosphorylation Molecular Biology PI3K/AKT/mTOR pathway Cell growth TOR Serine-Threonine Kinases Tumor Suppressor Proteins Body Weight Ribosomal Protein S6 Kinases 70-kDa Organ Size Cell Biology Lipid Metabolism Liver regeneration Liver Regeneration Enzyme Activation Mice Inbred C57BL Endocrinology Liver biology.protein TSC2 Signal Transduction RHEB |
| Zdroj: | Biochemical and Biophysical Research Communications. 437:146-150 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2013.06.056 |
| Popis: | Tuberin is a negative regulator of mTOR pathway. To investigate the function of tuberin during liver regeneration, we performed 70% hepatectomy on wild-type and Tsc2+/- mice. We found the tuberin phosphorylation correlated with mTOR activation during early liver regeneration in wild-type mice. However, liver regeneration in the Tsc2+/- mice was not enhanced. Instead, the Tsc2+/- livers failed to accumulate lipid bodies, and this was accompanied by increased mortality. These findings suggest that tuberin plays a critical role in liver energy balance by regulating hepatocellular lipid accumulation during early liver regeneration. These effects may influence the role of mTORC1 on cell growth and proliferation. |
| Databáze: | OpenAIRE |
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