The relationship between osteoarthritis of the hands, bone mineral density, and bone turnover markers
| Autor: | Nermin Hossam, Abir Naguib, Iman Soliman, Mohamed Samy, Ahmed Hamimi, Ahmed Semaya |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Bone mineral
musculoskeletal diseases medicine.medical_specialty Deoxypyridinoline medicine.diagnostic_test business.industry Osteoporosis Urology Physical examination General Medicine Osteoarthritis medicine.disease Bone remodeling Surgery Grip strength chemistry.chemical_compound chemistry Hand osteoarthritis medicine Bone mineral density business Bone turnover markers Body mass index |
| Zdroj: | Alexandria Journal of Medicine; Vol 47, No 2 (2011) |
| ISSN: | 2090-5068 2090-2948 1110-0834 |
| DOI: | 10.1016/j.ajme.2011.06.009 |
| Popis: | Aim: To investigate the relationship between hand osteoarthritis (HOA), bone mineral density (BMD), and bone turnover markers.Methods: Twenty post-menopausal women aged 50–73 years (mean: 62.4± 6.5) diagnosed with HOA were recruited along with 10 age-matched post-menopausal women with no signs of HOA as the control group. Both groups had postero-anterior hand radiographs taken and evaluatedaccording to the Kellgren–Lawrence scale to assess OA severity. They underwent thorough clinical examination including measurement of body mass index (BMI). They completed the AUSCAN questionnaire. Grip strength was measured using a hand held dynamometer and lateral pinchstrength was measured using a pinchmeter. They underwent BMD measurement at the hip and wrist using Dual energy X-ray absorptiometry. Furthermore, they had serum osteocalcin and urinary deoxypyridinoline (DPD) measured.Results: There was no statistically significant difference in T-scores of the hip (P = 0.168) and wrist (P = 0.45) between the patients and the controls. However, six patients (30%) had osteoporosis. A total of 12 patients had diminished BMD at the hip. There was no significant increase inserum osteocalcin levels in patients compared to controls (P = 0.382). However, urinary DPD was significantly elevated in the patient group compared to the controls, (P |
| Databáze: | OpenAIRE |
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