Prospective evaluation of topical antibiotics for preventing infections in uncomplicated soft-tissue wounds repaired in the ED
| Autor: | Jerry L. Karr, John J. Lorette, Marco Coppola, Daniel J. Dire, David A. Dwyer |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Petrolatum medicine.drug_class medicine.medical_treatment Administration Topical Antibiotics Silver sulfadiazine Vial Ointments Pharmacotherapy Bacitracin Injury Severity Score Double-Blind Method medicine Humans Prospective Studies Prospective cohort study Saline Polymyxin B Debridement integumentary system business.industry Neomycin General Medicine Silver Sulfadiazine Surgery Anti-Bacterial Agents Drug Combinations Anesthesia Emergency Medicine Wound Infection Drug Therapy Combination Female business Emergency Service Hospital medicine.drug |
| Zdroj: | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2(1) |
| ISSN: | 1069-6563 |
| Popis: | Objective: To determine differences in infection rates among uncomplicated, repaired wounds managed with: topical bacitracin zinc (BAC); neomycin sulfate, bacitracin zinc, and polymyxin B sulfate combination (NEO); silver sulfadiazine (SIL); and petrolatum (PTR). Methods: This was a prospective, randomized, double-blind, placebo-controlled study conducted at a military community hospital with an emergency medicine residency program. Patients were enrolled if they: presented to the ED within 12 hours of injury and did not have puncture wounds, allergies to the agents used, or a history of immunocompromise; were not receiving antibiotics, chemotherapy, or steroids at the time of presentation; had not taken antibiotics within the preceding seven days; did not have an underlying fracture; and were not pregnant as determined by history. Local anesthetics without epinephrine and high-pressure irrigation with normal saline were used for all the patients. Wound scrubbing, debridement, and polyglactin subcutaneous (SQ) suture placement were carried out when necessary. Interrupted simple sutures using a monofilament, nonabsorbable material were used for skin closure. Numbered, randomized vials were given to all patients, with standardized instructions to inspect, clean, and redress their wounds three times a day. The wounds were evaluated for clinical infection at the time of follow-up. Results: Among the groups, there was no difference in patient ages; gender; wound location, type, length, or depth; time elapsed from injury to ED treatment; number of wounds scrubbed or necessitating debridement; number of SQ and cutaneous sutures used; and rate of compliance with returning the used vial of dispensed topical agent. The wound infection rates for the treatment groups were: BAC, six of 109 (5.5%); NEO, five of 110 (4.5%); SIL, 12 of 99 (12.1%); and PTR, 19 of 108 (17.6%) (p = 0.0034). Conclusion: The use of topical antibiotics resulted in significantly lower infection rates than did the use of a petrolatum control. BAC and NEO had the lowest wound infection rates. |
| Databáze: | OpenAIRE |
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