The association of low vitamin k status with mortality in a cohort of 138 hospitalized patients with covid-19
| Autor: | Liv Rabøl Andersen, Sanne Marie Thysen, Niklas Rye Jørgensen, Henrik L. Jørgensen, Freja Bach Kampmann, Thomas Benfield, Allan Linneberg, Håkon Sandholt, Simone Bastrup Israelsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Vitamin K 030204 cardiovascular system & hematology Gastroenterology Cohort Studies vitamin K 0302 clinical medicine Matrix gla protein TX341-641 Hospital Mortality 030212 general & internal medicine Extracellular Matrix Proteins education.field_of_study Nutrition and Dietetics biology Hazard ratio Middle Aged Hospitalization Cohort Regression Analysis Female Cohort study Adult medicine.medical_specialty Population Article Young Adult 03 medical and health sciences Internal medicine Diabetes mellitus medicine Humans education Blood Coagulation Survival analysis thrombosis Aged Proportional Hazards Models Matrix Gla Protein Proportional hazards model business.industry Nutrition. Foods and food supply SARS-CoV-2 Calcium-Binding Proteins COVID-19 Thrombosis medicine.disease Elastic fiber elastic fiber biology.protein Vitamin K Deficiency business Biomarkers Food Science |
| Zdroj: | Linneberg, A, Kampmann, F B, Israelsen, S B, Andersen, L R, Jørgensen, H L, Sandholt, H, Jørgensen, N R, Thysen, S M & Benfield, T 2021, ' The association of low vitamin k status with mortality in a cohort of 138 hospitalized patients with covid-19 ', Nutrients, vol. 13, no. 6, 1985 . https://doi.org/10.3390/nu13061985 Nutrients Volume 13 Issue 6 Nutrients, Vol 13, Iss 1985, p 1985 (2021) |
| DOI: | 10.3390/nu13061985 |
| Popis: | It has recently been hypothesized that vitamin K could play a role in COVID-19. We aimed to test the hypotheses that low vitamin K status is a common characteristic of patients hospitalized with COVID-19 compared to population controls and that low vitamin K status predicts mortality in COVID-19 patients. In a cohort of 138 COVID-19 patients and 138 population controls, we measured plasma dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which reflects the functional vitamin K status in peripheral tissue. Forty-three patients died within 90 days from admission. In patients, levels of dp-ucMGP differed significantly between survivors (mean 877 95% CI: 778 995) and non-survivors (mean 1445 95% CI: 1148 1820). Furthermore, levels of dp-ucMGP (pmol/L) were considerably higher in patients (mean 1022 95% CI: 912 1151) compared to controls (mean 509 95% CI: 485 540). Cox regression survival analysis showed that increasing levels of dp-ucMGP (reflecting low vitamin K status) were associated with higher mortality risk (sex- and age-adjusted hazard ratio per doubling of dp-ucMGP was 1.49, 95% CI: 1.03 2.24). The association attenuated and became statistically insignificant after adjustment for co-morbidities (sex, age, CVD, diabetes, BMI, and eGFR adjusted hazard ratio per doubling of dp-ucMGP was 1.22, 95% CI: 0.82 1.80). In conclusion, we found that low vitamin K status was associated with mortality in patients with COVID-19 in sex- and age-adjusted analyses, but not in analyses additionally adjusted for co-morbidities. Randomized clinical trials would be needed to clarify a potential role, if any, of vitamin K in the course of COVID-19. |
| Databáze: | OpenAIRE |
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