Androstenediol reverses steroid-inhibited wound healing

Autor:	Kevin R. Ward, Roger M. Loria, Nathan B. Menke, V. Ramana Feeser, Robert F. Diegelmann
Rok vydání:	2009
Předmět:	Androstenediol Male medicine.medical_specialty Contraction (grammar) medicine.medical_treatment Dermatology Methylprednisolone Steroid Mice chemistry.chemical_compound Anabolic Agents Immune system Internal medicine Animals Medicine Immune Regulators Glucocorticoids Skin Wound Healing business.industry Disease Models Animal Endocrinology chemistry Wounds and Injuries Surgery Full thickness business Wound healing Hormone
Zdroj:	Wound Repair and Regeneration. 17:758-761
ISSN:	1524-475X 1067-1927
DOI:	10.1111/j.1524-475x.2009.00528.x
Popis:	It is well recognized that stress of any nature will cause a delay in the wound healing response. This delayed healing response appears closely associated with immune regulators. In this study, CD-1 mice were injected with a long acting form of methyl prednisolone to cause a steroid-induced immune suppression. After 24 hours, two 6-mm full thickness wounds were placed on the animals' backs and one group of animals received the immune-regulating hormone, androstenediol. Wound contraction was quantified by planimetry for the subsequent 14 days. Animals that were stressed with methyl prednisolone but receiving androstenediol contracted their open wounds at faster rates compared with methyl prednisolone-stressed animals treated with the vehicle alone. These findings suggest that restoration of immune regulation by androstenediol can reverse the delayed open wound contraction secondary to steroid stress.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a321b3d41af485f0f565742f259581c3 https://doi.org/10.1111/j.1524-475x.2009.00528.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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