Bioactive homogentisic acid derivatives from fruits and flowers of Miliusa velutina
| Autor: | Vittaya Amornkitbamrung, Kwanjai Kanokmedhakul, Trinop Promgool, Saowanit Tongpim, Sarawut Tontapha, Somdej Kanokmedhakul, Winai Jamjan |
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| Rok vydání: | 2019 |
| Předmět: |
Phytochemicals
Bacillus cereus Annonaceae Flowers Microbial Sensitivity Tests Gram-Positive Bacteria medicine.disease_cause Mycobacterium tuberculosis chemistry.chemical_compound Cell Line Tumor Chlorocebus aethiops Drug Discovery medicine Animals Humans Homogentisic acid Cytotoxicity Homogentisic Acid Vero Cells Pharmacology Chromatography Molecular Structure biology General Medicine Thailand biology.organism_classification Antineoplastic Agents Phytogenic Anti-Bacterial Agents chemistry Staphylococcus aureus Fruit Vero cell Miliusa velutina Bacteria |
| Zdroj: | Fitoterapia. 134:65-72 |
| ISSN: | 0367-326X |
| Popis: | Chromatographic separation of fruits and flowers of the Thai medicinal plant, Miliusa velutina, resulted in the isolation of five new rare homogentisic acid derivatives, miliusanal (1) and miliusanones A-D (2–5), together with fifteen known secondary metabolites (6–20). Their structures were determined through the use of extensive spectroscopic data. The absolute configurations of homogentisic acid derivatives 2–7 were identified using NOESY data and a comparison of experimental and calculated ECD spectral data. Compounds 2, 3, 6, and 7 showed antimalarial activity with IC50 values in the range of 3.3–5.2 μg/mL. Compound 6 also showed activity against Mycobacterium tuberculosis with an MIC value of 50 μg/mL. Compounds 1–3, 6 and 7 exhibited cytotoxicity againt KB, MCF-7, NCI-H187 and Vero cell lines with IC50 values in the range of 5.8–40.4 μg/mL. In addition, compounds 1, 2 and 6 showed moderate antibacterial activities against three Gram-positive bacteria (Bacillus cereus, Staphylococcus aureus, and Methicillin resistant S. aureus) with MICs in the range of 32–64 μg/mL. |
| Databáze: | OpenAIRE |
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