Medial prefrontal D1 dopamine neurons control food intake
| Autor: | Ralph J. DiLeone, David M Grimaldi, Douglas J. Guarnieri, Maysa Sarhan, Nandakumar S. Narayanan, Karl Deisseroth, Rong-Jian Liu, Catherine E. Brayton, Carol A. Gianessi, Benjamin B. Land, George K. Aghajanian |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Patch-Clamp Techniques Time Factors Biophysics Prefrontal Cortex Mice Transgenic Optogenetics In Vitro Techniques Amygdala Article Functional Laterality Photostimulation Membrane Potentials Eating Mice Channelrhodopsins Dopamine Neural Pathways medicine Animals Axon Prefrontal cortex Neurons Analysis of Variance General Neuroscience Receptors Dopamine D1 Neural Inhibition Electric Stimulation Mice Inbred C57BL Luminescent Proteins medicine.anatomical_structure nervous system Gene Expression Regulation Female Neuron Psychology Calcium-Calmodulin-Dependent Protein Kinase Type 2 Food Deprivation Neuroscience Photic Stimulation medicine.drug Basolateral amygdala |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and optogenetic photostimulation of D1 neurons increases feeding. Conversely, inhibition of D1 neurons decreases intake. Stimulation-based mapping of prefrontal D1 neuron projections implicates the medial basolateral amygdala (mBLA) as a downstream target of these afferents. mBLA neurons activated by prefrontal D1 stimulation are CaMKII positive and closely juxtaposed to prefrontal D1 axon terminals. Finally, photostimulating these axons in the mBLA is sufficient to increase feeding, recapitulating the effects of mPFC D1 stimulation. These data describe a new circuit for top-down control of food intake. |
| Databáze: | OpenAIRE |
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