External Beam Radiation Therapy for Resectable Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis
| Autor: | Alexandra Rauch, Lars H. Lindner, Nina L. Jebsen, Philippe A Cassier, Sebastian Pratschke, Alessandro Gronchi, M. Kirschneck, Markus Albertsmeier, Jens Werner, Claus Belka, Falk Roeder, Martin K. Angele, Paul Sargos, S Hasenhütl |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Soft Tissue Neoplasms law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Survival rate Radiotherapy business.industry Soft tissue sarcoma Soft tissue Odds ratio medicine.disease Prognosis Radiation therapy Survival Rate 030220 oncology & carcinogenesis Meta-analysis 030211 gastroenterology & hepatology Surgery Radiology Sarcoma Neoplasm Recurrence Local business |
| Zdroj: | Annals of surgical oncology. 25(3) |
| ISSN: | 1534-4681 |
| Popis: | The aim of this study was to evaluate the role of preoperative and postoperative external beam radiation therapy (EBRT) in the treatment of resectable soft tissue sarcomas (STSs) of different tumor locations. A systematic literature search was performed to identify studies investigating the effects of EBRT (versus no EBRT) on local recurrence (LR) and overall survival (OS) or comparing different EBRT sequences. Random effects meta-analyses were calculated and presented as cumulative odds ratios (ORs). Sixteen studies (n = 3958 patients) comparing EBRT versus no EBRT, including one randomized controlled trial (RCT) in extremity sarcoma, were analyzed. EBRT appeared to reduce LR in both retroperitoneal tumors (OR 0.47, p |
| Databáze: | OpenAIRE |
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