mARC preoperative rectal cancer treatments vs. 3D conformal radiotherapy. A dose distribution comparative study

Autor: María Victoria de Torres Olombrada, Rocío Bermúdez Luna
Rok vydání: 2019
Předmět:
Male
Organs at Risk
Colorectal cancer
medicine.medical_treatment
Treatment outcome
Cancer Treatment
Toxicology
Pathology and Laboratory Medicine
030218 nuclear medicine & medical imaging
0302 clinical medicine
3d conformal radiotherapy
Medicine and Health Sciences
Booster Doses
Vaccines
Multidisciplinary
Proctectomy
Radiotherapy Dosage
Middle Aged
Neoadjuvant Therapy
Cancer treatment
Treatment Outcome
Infectious Diseases
Oncology
030220 oncology & carcinogenesis
Medicine
Female
Anatomy
Research Article
Clinical Oncology
Infectious Disease Control
Science
Bladder
Radiation Therapy
Dose distribution
Rectal Cancer
03 medical and health sciences
Exocrine Glands
Gastrointestinal Tumors
medicine
Arc therapy
Humans
Radiometry
Aged
Toxicity
business.industry
Rectal Neoplasms
Radiotherapy Planning
Computer-Assisted
Rectum
Cancers and Neoplasms
Biology and Life Sciences
Renal System
medicine.disease
Radiation therapy
Initial phase
Prostate Gland
Radiotherapy
Intensity-Modulated
Radiotherapy
Conformal
Clinical Medicine
business
Nuclear medicine
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0221262 (2019)
ISSN: 1932-6203
Popis: PurposemARC (modulated arc) is the arc therapy technique provided by Siemens. The present study analyses the dose distributions and treatment times corresponding to preoperative rectal cancer mARC treatments. The results are compared to those corresponding to 3D-CRT plans.MethodsThe plans of 30 patients, each having one mARC and one 3D-CRT plan, were evaluated. Every plan was calculated on a sequential two-phase treatment scheme with prescription doses of 45 Gy in the initial phase and 5.4 Gy in the boost phase. Dosimetric parameters and mean DVHs corresponding to the PTVs and OARs were assessed for both techniques.ResultsAll mARC plans were considered valid for treatment and yielded a highly significant improvement in the CI over 3D-CRT plans (p ConclusionsArc therapy plans with the mARC technique for preoperative rectal cancer treatment in a sequential two-phase treatment scheme provide important advantages in the PTVs and OARs. mARC plans show superior protection of the femoral heads, bladder and small bowel, similar to the results found with other more widespread arc therapy techniques.
Databáze: OpenAIRE
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