Assessment of the liver and spleen in children with Gaucher disease type I with diffusion-weighted MR imaging
| Autor: | Tarik Barakat, Heba El-Taher, Ahmed Abdel Khalek Abdel Razek, Khadiga M Ali, Ahmed Abdalla |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Pathology Adolescent Spleen Disease Gastroenterology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Effective diffusion coefficient Prospective Studies Child Diffusion-Weighted MR Imaging Prospective cohort study Molecular Biology Gaucher Disease business.industry Organ Size Cell Biology Hematology medicine.disease Mr imaging body regions Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Liver Child Preschool 030220 oncology & carcinogenesis Molecular Medicine Abdomen Female business Infiltration (medical) |
| Zdroj: | Blood Cells, Molecules, and Diseases. 68:139-142 |
| ISSN: | 1079-9796 |
| DOI: | 10.1016/j.bcmd.2016.12.004 |
| Popis: | Purpose To assess hepatic and splenic apparent diffusion coefficient (ADC) in children with Gaucher disease type I with diffusion-weighted MR imaging and to correlate hepatic and splenic ADC with parameters of disease severity. Subjects and methods Prospective study was conducted upon 25 children (11 treated and 14 untreated) with Gaucher disease and 12 age and sex matched control children. They underwent diffusion-weighted MR imaging of abdomen. Hepatic and splenic ADC and volume were calculated. Results There was statistically difference in hepatic and splenic apparent diffusion coefficient (P = 0.001) between patients and controls. The cutoff ADC of liver and spleen used to differentiate patients from controls were 0.47 and 0.39 × 10− 3 mm2 with area and curve of 0.947 and 0.886 respectively. There was significant difference in hepatic and splenic ADC between untreated and treated patients (P = 0.003 and 0.001). Hepatic ADC correlated with splenic volume (r = − 0.721), hepatic volume (r = − 0.555) and chitotriosidase (r = − 0.413). Splenic ADC correlated with splenic volume (r = − 0.652), hepatic volume (r = − 0.544) and chitotriosidase (r = − 0.355). Conclusion Hepatic and splenic ADC can detect hepatic and splenic infiltration in Gaucher disease and correlated with some parameters of disease severity. |
| Databáze: | OpenAIRE |
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