Preoperative Renal Insufficiency
| Autor: | Marny H. Shoham, Venod Narine, Jeanna D. Blitz, Yixin Fang, Samir Kendale, Paul Shekane, Beamy S. Sharma, Neeraj Mehta |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Gerontology medicine.medical_specialty Time Factors MEDLINE Renal function 030204 cardiovascular system & hematology Kidney urologic and male genital diseases Patient Readmission Risk Assessment Decision Support Techniques 03 medical and health sciences Postoperative Complications 0302 clinical medicine Predictive Value of Tests Risk Factors 030202 anesthesiology Internal medicine Odds Ratio medicine Electronic Health Records Humans Renal Insufficiency Aged Retrospective Studies Academic Medical Centers Chi-Square Distribution business.industry Retrospective cohort study Odds ratio Length of Stay Middle Aged medicine.disease Logistic Models Treatment Outcome Anesthesiology and Pain Medicine Surgical Procedures Operative Predictive value of tests Multivariate Analysis Female New York City business Risk assessment Chi-squared distribution Glomerular Filtration Rate Kidney disease |
| Zdroj: | Anesthesia & Analgesia. 123:1500-1515 |
| ISSN: | 0003-2999 |
| DOI: | 10.1213/ane.0000000000001573 |
| Popis: | Making a formal diagnosis of chronic kidney disease (CKD) in the preoperative setting may be challenging because of lack of longitudinal data. We explored the predictive value of a single reduced preoperative estimated glomerular filtration rate (eGFR) value on adverse patient outcomes in the first 30 days after elective surgery. We compared the rate of major postoperative adverse events, including 30-day readmission rate, hospital length of stay, infection, acute kidney injury (AKI), and myocardial infarction across patients with declining preoperative eGFR values. We hypothesized that there is an association between decreasing preoperative eGFR values and major postoperative morbidity including readmission within 30 days of discharge and that the reasons for unplanned readmissions may be associated with poor preoperative renal function.This was a retrospective analysis of the electronic health record of 39 989 adult patients who underwent elective surgery between June 2011 and July 2013 at our institution. Patients with reduced eGFR (60 mL/min/1.73 m) were identified and categorized by the stages of CKD that correlated with the preoperative eGFR value. Odds of readmission to our hospital within 30 days, as well as new diagnosis of AKI, myocardial infarction, and infection, were determined with multivariate logistic regression. The subset of patients who were readmitted within 30 days also were subdivided further into patients who had an eGFR60 mL/min/1.73 m and those with an eGFR ≥60 mL/min/1.73 m, as well as whether the readmission was planned or unplanned.Of the 4053 patients with eGFR60 mL/min/1.73 m, 3290 (81.2%) did not carry a preoperative diagnosis of CKD. Adjusted odds ratios of being readmitted were 1.48 (99% confidence interval [CI], 1.18-1.87; P.001) for eGFR 30 to 44 mL/min/1.73 m to 2.06 (99% CI, 1.32-3.23; P.001) for eGFR15 mL/min/1.73 m compared with patients with a preoperative eGFR value ≥60 mL/min/1.73 m. Patients with a lower eGFR also demonstrated increasing odds of AKI from 2.78 (99% CI, 1.86-4.17; P.001) for eGFR 45 to 59 mL/min/1.73 m to 3.81 (99% CI, 1.68-8.16; P.001) for eGFR15 mL/min/1.73 m.This study highlights that preoperative renal insufficiency may be underreported and appears to be significantly associated with postoperative complications. It extends the association between a single low preoperative eGFR and postoperative morbidity to a broader range of surgical populations than previously described. Our results suggest that preoperative calculation of eGFR may be a relatively low-cost, readily available tool to identify patients who are at an increased risk of readmission within 30 days of surgery and postoperative morbidity in patients presenting for elective surgery. |
| Databáze: | OpenAIRE |
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