ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review
| Autor: | Christian Calvo-Henriquez, Thomas Radulesco, Justin Michel, Carlos M. Chiesa-Estomba, Giacomo De Riu, Julien Hsieh, Géraldine Descamps, Leigh J. Sowerby, Luigi Angelo Vaira, Jerome R. Lechien, Giovanni Cammaroto, Sven Saussez, Stéphane Hans, Isabelle Gengler, Maria Rosaria Barillari |
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| Přispěvatelé: | Institut universitaire des systèmes thermiques industriels (IUSTI), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Lechien, J. R., Radulesco, T., Calvo-Henriquez, C., Chiesa-Estomba, C. M., Hans, S., Barillari, M. R., Cammaroto, G., Descamps, G., Hsieh, J., Vaira, L., De Riu, G., Sowerby, L., Gengler, I., Michel, J., Saussez, S. |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell type medicine.medical_specialty Pathology Coronaviru Population ACE2 Review Cochrane Library urologic and male genital diseases TMPRSS2 Pathology and Forensic Medicine 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases medicine Animals Humans 10. No inequality education COVID education.field_of_study Head Neck SARS-CoV-2 business.industry Serine Endopeptidases COVID-19 3. Good health Coronavirus 030104 developmental biology Oncology Otorhinolaryngology 030220 oncology & carcinogenesis Oral and maxillofacial surgery Angiotensin-Converting Enzyme 2 Animal studies business Head Neck hormones hormone substitutes and hormone antagonists |
| Zdroj: | Head and Neck Pathology Head and Neck Pathology, 2020, 15, pp.225-235. ⟨10.1007/s12105-020-01212-5⟩ |
| ISSN: | 1936-0568 1936-055X |
| Popis: | International audience; To review the data regarding the expression of angiotensin converting enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2) in head and neck tissue. Scopus, Cochrane Library, Medrxiv, Google Scholar and PubMED/MEDLINE were searched by four independent investigators for studies investigating ACE2 or TMPRSS2 expressions in head and neck tissues. The following outcomes were considered: sample origin (animal versus human); detection method; anatomical location and cell types. PRISMA checklist and modified population, intervention, comparison, outcome, timing and setting (PICOTS) framework were used to perform the review. Of the 24 identified studies, 17 met our inclusion criteria. Thirteen studies were conducted during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. ACE2 and TMPRSS2 were expressed in oral, pharyngeal, sinusonasal human mucosa. The following cell types expressed ACE2: basal, apical, goblet, minor salivary, and endothelial cells. TMPRSS2 was found in goblet and apical respiratory cells. ACE2 and TMPRSS2 were found in the olfactory region, especially in sustentacular non-neural and neural stem cells. Animal studies suggested that ACE2 expression may vary regarding age. There was an important heterogeneity between studies in the methods used to detect ACE2 and TMPRSS2, leading to a potential identification bias. The SARS-CoV-2 receptors, ACE2 and TMPRSS2, are both expressed in many head and neck tissues, enabling the viral entry into the host organism. |
| Databáze: | OpenAIRE |
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