Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen
| Autor: | Sara N. Burke, Dominic P. D’Agostino, Quinten P. Federico, Nedi Ferekides, Keila T. Campos, Abbi R. Hernandez, Leah M. Truckenbrod, Meagan Hoppe, Brianna Moon |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Aging medicine.medical_treatment chemistry.chemical_compound Internal medicine Rats Inbred BN Intermittent fasting medicine Animals Glycolysis glucose Low carbohydrate Glycogen business.industry intermittent fasting Cell Biology Metabolism Ketosis Carbohydrate medicine.disease Adaptation Physiological Rats Inbred F344 Rats Disease Models Animal Endocrinology Epinephrine chemistry ketogenic diet keto-adaptation business Diet Ketogenic diet Ketogenic diet medicine.drug Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | The ability to switch between glycolysis and ketosis promotes survival by enabling metabolism through fat oxidation during periods of fasting. Carbohydrate restriction or stress can also elicit metabolic switching. Keto-adapting from glycolysis is delayed in aged rats, but factors mediating this age-related impairment have not been identified. We measured metabolic switching between glycolysis and ketosis, as well as glycogen dynamics, in young and aged rats undergoing time-restricted feeding (TRF) with a standard diet or a low carbohydrate ketogenic diet (KD). TRF alone reversed markers of insulin-related metabolic deficits and accelerated metabolic switching in aged animals. A KD+TRF, however, provided additive benefits on these variables. Remarkably, the ability to keto-adapt was not related to glycogen levels and KD-fed rats showed an enhanced elevation in glucose following epinephrine administration. This study provides new insights into the mechanisms of keto-adaptation demonstrating the utility of dietary interventions to treat metabolic impairments across the lifespan. |
| Databáze: | OpenAIRE |
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