The relation of adult bronchial responsiveness to serious childhood respiratory illness in the ECRHS
| Autor: | Deborah Jarvis, Shyamali C. Dharmage, Cecilie Svanes, Susan Chinn, Christer Janson |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Spirometry Pulmonary and Respiratory Medicine Pediatrics medicine.medical_specialty Vital Capacity Population Bronchoconstrictor Agents Atopy Risk Factors Forced Expiratory Volume Respiratory infection medicine Humans Respiratory system education Respiratory Tract Infections Methacholine Chloride Body mass index education.field_of_study medicine.diagnostic_test business.industry Bronchial responsiveness Smoking Respiratory disease Age Factors Immunoglobulin E medicine.disease Cross-Sectional Studies medicine.anatomical_structure Immunology Female Methacholine Bronchial Hyperreactivity business Respiratory tract medicine.drug |
| Zdroj: | Respiratory Medicine. 101(5):983-988 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2006.09.004 |
| Popis: | Summary Background Respiratory symptoms in adulthood have been found to be associated with childhood respiratory infection, but few studies have analyzed adult bronchial responsiveness (BHR) with adequate adjustment for known risk factors. Objective To estimate the relation of BHR with serious childhood respiratory infections in a large population study. Methods The European Community Respiratory Health Survey (ECRHS) was a cross-sectional population-based survey in 34 centers. Data on serious respiratory infections before the age of 5 years and possible confounders were obtained from a questionnaire administered in the clinic. Blood samples were taken for measurement of total immunoglobulin E (IgE) and specific IgE to four common allergens, and spirometry and bronchial challenge with methacholine were performed. A continuous measure of BHR was analyzed by multiple regression, in 11,282 participants, in relation to serious respiratory infection and other potential risk factors, adjusted for center and major determinants of adult BHR. Results Those reporting a serious childhood respiratory infection had greater BHR, by an amount corresponding to approximately 0.23 doubling doses (95% confidence interval 0.02–0.44) of the amount of methacholine causing a 20% fall (PD 20 ) in forced expiratory volume in 1s (FEV 1 ). All childhood factors explained less than 0.3% of variation in BHR in addition to over 20% by factors measured in adulthood. The relation of BHR to BMI was confined to smokers. Conclusions We found an effect of serious childhood respiratory infection on adult BHR, but this was small in comparison to relations of BHR to IgE-sensitization and airway caliber. |
| Databáze: | OpenAIRE |
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