P-STAT3 and IL-17 in tumor tissues enhances the prognostic value of CEA and CA125 in patients with lung adenocarcinoma

Autor: Chuan-Long Gu, Xiao-Ke Chen, Xiao-Ming Zhang, Jun-Qiang Fan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Oncology
Lung adenocarcinoma
Lung Neoplasms
endocrine system diseases
0302 clinical medicine
Carcinoembryonic antigen
CEA
p-STAT3
Medicine
Stage (cooking)
STAT3
Aged
80 and over
biology
Interleukin-17
General Medicine
Middle Aged
Prognosis
female genital diseases and pregnancy complications
Survival Rate
IL-17
medicine.anatomical_structure
Lymphatic Metastasis
030220 oncology & carcinogenesis
Adenocarcinoma
Female
Interleukin 17
Adult
STAT3 Transcription Factor
medicine.medical_specialty
Adenocarcinoma of Lung
RM1-950
03 medical and health sciences
CA125
Internal medicine
Biomarkers
Tumor
Humans
In patient
Aged
Neoplasm Staging
Pharmacology
Inflammation
Lung
business.industry
medicine.disease
digestive system diseases
Carcinoembryonic Antigen
030104 developmental biology
CA-125 Antigen
biology.protein
STAT protein
Therapeutics. Pharmacology
business
Zdroj: Biomedicine & Pharmacotherapy, Vol 125, Iss, Pp 109871-(2020)
ISSN: 0753-3322
Popis: Aim The present study aimed to examine the capability of p- signal transducer and activator of transcription (STAT)3 and interleukin-17 (IL-17), along with two known tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125), for disease prognosis. Moreover, the associations among biomarkers and clinicopathological parameters were evaluated to uncover the potential mechanisms responsible for their correlations with lung adenocarcinoma (LAD) prognosis. Methods Five LAD-related parameters were used in the study: CEA, CA125, STAT3, p-STAT3, and IL-17. Spearman and chi-square correlation tests were used to explore the relationships between some clinicopathological variables and parameter expression levels and the associations among these five parameters. Results The disease-specific survival decreased with the positive expression of CEA, CA125, p-STAT3, and IL-17, with no significant difference in the expression level of STAT3. Combinations of p-STAT3 and IL-17, CEA and p-STAT3, CEA and IL-17, CA125 and p-STAT3, and CA125 and IL-17 had higher predictive values in LAD prognosis. The correlation analyses indicated the synergic activities of STAT3, p-STAT3, and IL-17 and the coordinated expression of CEA, CA125, p-STAT3, and IL-17. The tumor-node-metastasis (TNM) stage significantly correlated with the levels of CA125 and p-STAT3. Conclusions Elevated levels of CEA, CA125, p-STAT3, and IL-17 alone and/or combinations of p-STAT3 and IL-17, CEA and p-STAT3, CEA and IL-17, CA125 and p-STAT3, and CA125 and IL-17 were recommended as the prognostic predictors of unfavorable clinical outcomes in patients with postoperative LAD. Also, p-STAT3 and IL-17 combined with CA125 and CEA helped in predicting the overall survival of patients with LAD and informing the TNM stage.
Databáze: OpenAIRE
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