P-STAT3 and IL-17 in tumor tissues enhances the prognostic value of CEA and CA125 in patients with lung adenocarcinoma
Autor: | Chuan-Long Gu, Xiao-Ke Chen, Xiao-Ming Zhang, Jun-Qiang Fan |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Oncology Lung adenocarcinoma Lung Neoplasms endocrine system diseases 0302 clinical medicine Carcinoembryonic antigen CEA p-STAT3 Medicine Stage (cooking) STAT3 Aged 80 and over biology Interleukin-17 General Medicine Middle Aged Prognosis female genital diseases and pregnancy complications Survival Rate IL-17 medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Adenocarcinoma Female Interleukin 17 Adult STAT3 Transcription Factor medicine.medical_specialty Adenocarcinoma of Lung RM1-950 03 medical and health sciences CA125 Internal medicine Biomarkers Tumor Humans In patient Aged Neoplasm Staging Pharmacology Inflammation Lung business.industry medicine.disease digestive system diseases Carcinoembryonic Antigen 030104 developmental biology CA-125 Antigen biology.protein STAT protein Therapeutics. Pharmacology business |
Zdroj: | Biomedicine & Pharmacotherapy, Vol 125, Iss, Pp 109871-(2020) |
ISSN: | 0753-3322 |
Popis: | Aim The present study aimed to examine the capability of p- signal transducer and activator of transcription (STAT)3 and interleukin-17 (IL-17), along with two known tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125), for disease prognosis. Moreover, the associations among biomarkers and clinicopathological parameters were evaluated to uncover the potential mechanisms responsible for their correlations with lung adenocarcinoma (LAD) prognosis. Methods Five LAD-related parameters were used in the study: CEA, CA125, STAT3, p-STAT3, and IL-17. Spearman and chi-square correlation tests were used to explore the relationships between some clinicopathological variables and parameter expression levels and the associations among these five parameters. Results The disease-specific survival decreased with the positive expression of CEA, CA125, p-STAT3, and IL-17, with no significant difference in the expression level of STAT3. Combinations of p-STAT3 and IL-17, CEA and p-STAT3, CEA and IL-17, CA125 and p-STAT3, and CA125 and IL-17 had higher predictive values in LAD prognosis. The correlation analyses indicated the synergic activities of STAT3, p-STAT3, and IL-17 and the coordinated expression of CEA, CA125, p-STAT3, and IL-17. The tumor-node-metastasis (TNM) stage significantly correlated with the levels of CA125 and p-STAT3. Conclusions Elevated levels of CEA, CA125, p-STAT3, and IL-17 alone and/or combinations of p-STAT3 and IL-17, CEA and p-STAT3, CEA and IL-17, CA125 and p-STAT3, and CA125 and IL-17 were recommended as the prognostic predictors of unfavorable clinical outcomes in patients with postoperative LAD. Also, p-STAT3 and IL-17 combined with CA125 and CEA helped in predicting the overall survival of patients with LAD and informing the TNM stage. |
Databáze: | OpenAIRE |
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