Green synthesis of magnesium and cobalt oxide nanoparticles using Euphorbia tirucalli: Characterization and potential application for breast cancer inhibition

Autor:	Mamello Sekhoacha, Relebohile Lefojane, Samson Sitheni Mashele, Ipeleng Kopano Rosinah Kgosiemang, Zandile Madlanga, Paballo Direko
Rok vydání:	2020
Předmět:	biology Magnesium Euphorbia tirucalli fungi technology industry and agriculture chemistry.chemical_element Nanoparticle 02 engineering and technology Anti proliferative 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences 0104 chemical sciences Inorganic Chemistry chemistry Physical and Theoretical Chemistry 0210 nano-technology Cobalt oxide Nuclear chemistry
Zdroj:	Inorganic and Nano-Metal Chemistry. 50:1070-1080
ISSN:	2470-1564 2470-1556
DOI:	10.1080/24701556.2020.1735422
Popis:	The current study reports on the synthesis of magnesium oxide (MgONPs) and cobalt oxide (CoONPs) nanoparticles using the aerial parts of Euphorbia tirucalli and further characterizing and evaluating the anti-proliferative effect of the nanoparticles (NPs) on MCF-7 breast cancer cell line. The synthesized NPs were characterized using ultraviolet–visible spectrophotometry (UV-vis), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Anti-proliferative activity of E. tirucalli extracts and synthesized NPs was assessed using 3-(4,5-dimethylthiazol-2-yl)−2,5-diphenyl tetrazolium bromide (MTT) assay. Formation of the NPs was confirmed by a color change from brown to black (MgONPs) and pink (CoONPs), respectively. Two UV absorbance peaks were observed at 305 and 508 cm−1 confirming the formation of CoONPs. Traces of cobalt and oxygen as well as magnesium and oxygen were detected by EDS. The NPs sizes ranging between 1 µm and 100 nm was confirmed by TEM for both NPs. The hexane (Hex) and dichloromethane (DCM) extracts of E. tirucalli exhibited cell growth inhibition of MCF-7 cells with IC50 values of 10 µg/ml; while CoONPs showed increased cell growth inhibition with an IC50 values
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30f84064b574958effc5278908b3516 https://doi.org/10.1080/24701556.2020.1735422 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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