White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly
| Autor: | Günther Deuschl, Inken Toedt, Stephan Wolff, Kirsten E. Zeuner, Johannes Busse, Daniela Berg, Oliver Granert, Ulf Jensen-Kondering, Jos Steffen Becktepe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Inversion recovery Significant negative correlation Multiple linear regression model Fluid-attenuated inversion recovery behavioral disciplines and activities White matter 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine RC346-429 essential tremor Tremor amplitude Original Research Essential tremor business.industry white matter hyperintensities medicine.disease Hyperintensity 030104 developmental biology medicine.anatomical_structure Neurology tremor severity Cardiology accelerometric tremor frequency Neurology (clinical) Neurology. Diseases of the nervous system business 030217 neurology & neurosurgery senile tremors |
| Zdroj: | Frontiers in Neurology Frontiers in Neurology, Vol 12 (2021) |
| ISSN: | 1664-2295 |
| Popis: | Background: Essential tremor (ET) occurs with steeply increasing prevalence in the elderly, and apart from disease duration, age is independently associated with an increase of tremor amplitude and a decrease of frequency. White matter hyperintensities (WMHs) are a common finding in the elderly, and their role in the pathophysiology of ET is unknown. The aims of this study were to examine whether ET patients differ in their total or region-specific WMH volumes from healthy controls and to determine the impact of WMH on tremor characteristics.Methods: A total of 47 elderly ET patients with a mean age of 72 years and 39 age-matched healthy controls underwent a thorough clinical assessment and 3T MRI. Total WMH volumes were derived from T2-weighted fluid-attenuated inversion recovery (FLAIR) MR images. Additionally, region of interest-based WMH volumes for the Johns Hopkins University (JHU) white matter tracts and labels were calculated, and WMHs were assessed semiquantitatively using the Fazekas scale.Results: Essential tremor patients and healthy controls did not differ in their total or tract-specific WMH volumes or Fazekas scores. However, WMH volume was significantly positively correlated with tremor severity on the TETRAS scale, and there was a significant negative correlation with the mean accelerometric tremor frequency. In a multiple linear regression model including disease duration, age, and age-adjusted total WMH volume, only the WMH volume significantly predicted tremor severity, while age and disease duration were not significant.Conclusion: We found evidence for a direct association between WMH volume and tremor severity. If confirmed by larger studies, our findings could explain the well-known relation between age and tremor severity. |
| Databáze: | OpenAIRE |
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