The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment
| Autor: | Nicola Silvestris, Michela Del Prete, Riccardo Giampieri, Mario Scartozzi, Marco D'Anzeo, Stefano Cascinu, Maristella Bianconi, Luca Faloppi |
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| Rok vydání: | 2014 |
| Předmět: |
Carcinoma
Hepatocellular Pharmaceutical Science Review Biology Bioinformatics medicine.disease_cause Analytical Chemistry lcsh:QD241-441 lcsh:Organic chemistry Drug Discovery microRNA Gene expression Biomarkers Tumor medicine Carcinoma Humans Molecular Targeted Therapy HCC Physical and Theoretical Chemistry Regulation of gene expression Liver Neoplasms Organic Chemistry Cancer RNA Genetic Therapy hepatocellular carcinoma Prognosis medicine.disease digestive system diseases Gene Expression Regulation Neoplastic MicroRNAs Chemistry (miscellaneous) Hepatocellular carcinoma miRNAs Molecular Medicine Carcinogenesis |
| Zdroj: | Molecules, Vol 19, Iss 5, Pp 6393-6406 (2014) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation. Recent evidences have shown that they are involved in many biological processes, from development and cell-cycle regulation to apoptosis. miRNAs can behave as tumor suppressor or promoter of oncogenesis depending on the cellular function of their targets. Moreover, they are frequently dysregulated in HCC. In this review we summarize the latest findings of miRNAs regulation in HCC and their role as potentially diagnostic and prognostic biomarkers for HCC. We highlight development of miRNAs as potential therapeutic targets for HCC. |
| Databáze: | OpenAIRE |
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