Rapid quantitative determination of seven anthracyclines and their hydroxy metabolites in body fluids
| Autor: | Eppo van der Kleijn, Rita J.M. Dirks, M. J. M. Oosterbaan, Tom B. Vree |
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| Rok vydání: | 1984 |
| Předmět: |
Detection limit
Chromatography Antibiotics Antineoplastic Anthracycline Plasma samples Naphthacenes Chemistry Carubicin General Chemistry Hydroxylation Quantitative determination Kinetics Dogs Spectrometry Fluorescence Pharmacokinetics Drug Stability Doxorubicin Animals Humans Chromatography High Pressure Liquid |
| Zdroj: | Journal of chromatography. 306 |
| Popis: | A reversed-phase high-performance liquid chromatographic method is described for the determination of seven anthracycline analogues and their hydroxy metabolites. The method is suitable for analysis of 30 plasma samples a day. The detection limit is 0.5 ng/ml for all compounds. Examples of the pharmacokinetics of adriamycin and carminomycin in man are shown. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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