Novel and efficient synthesis and antifungal evaluation of 2,3-functionalized cholestane and androstane derivatives
| Autor: | Branko S. Jursic, Sunil K. Upadhyay, Clinton C. Creech, Donna M. Neumann |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Antifungal
Antifungal Agents medicine.drug_class medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Biochemistry Chemical synthesis Steroid Structure-Activity Relationship chemistry.chemical_compound Biological property Drug Discovery medicine Organic chemistry Molecular Biology Cholestanes Chemistry Organic Chemistry Cholesterol Drug development Molecular Medicine Cholestane Androstane Androstanes |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 20:7372-7375 |
| ISSN: | 0960-894X |
| Popis: | Synthetic modifications of cholesterol and other traditional steroid molecules have become a promising area for the exploration and development of novel antifungal agents, especially with respect to the development of fatty-acid esters of steroids. In addition, 2,3-functionalized steroids are also compounds with potentially interesting biological properties and proper functionalization of 2,3-steroids can lead to the development of efficient syntheses of building blocks for novel fatty-acid esters of steroids. In this Letter, we outline a novel and efficient approach to the synthesis of 2,3-functionalized cholestane and androstane derivatives and present their promising preliminary antifungal activities against a number of fungal species. |
| Databáze: | OpenAIRE |
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