Serum salusin-alpha level in rheumatoid arthritis
| Autor: | Mehmet Balin, Ahmet Isik, Süleyman Serdar Koca, Necati Dagli, Metin Ozgen, Bilal Ustundag |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Serum Systemic disease medicine.medical_specialty Carotid Artery Common Physiology Clinical Biochemistry Behcet's disease Biochemistry Arthritis Rheumatoid Coronary artery disease Pathogenesis Cellular and Molecular Neuroscience Endocrinology Immunopathology Internal medicine medicine Humans Body Weights and Measures Foam cell Autoimmune disease Interleukin-6 Tumor Necrosis Factor-alpha business.industry Behcet Syndrome Middle Aged Atherosclerosis medicine.disease Case-Control Studies Rheumatoid arthritis Immunology Intercellular Signaling Peptides and Proteins Female Tunica Intima business |
| Zdroj: | Regulatory Peptides. 167:125-128 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/j.regpep.2010.12.003 |
| Popis: | Rheumatoid arthritis (RA), a chronic inflammatory disease, leads to early and accelerated atherosclerosis; however, its pathogenesis is not yet fully documented. Salusin-α and β are novel bioactive peptides. Salusin-α suppresses macrophage foam cell formation, while salusin-β stimulates. Moreover, decreased serum salusin-α level has been reported previously in patients with coronary artery disease. The aims of the study were to assess serum salusin-α level and its association with predictors of atherosclerosis in a cohort of patients with RA. The study included 56 RA patients, 37 Behcet's disease (BD) patients, and 29 healthy controls (HC). TNF-α, IL-6 and salusin-α levels, homeostasis model assessment (HOMA-IR) index and common carotid intima-media thickness (IMT) were determined. In the RA and BD groups, salusin-α levels (p0.001 and p0.01, respectively) and IMTs (p0.001 for both) were higher compared to the HC group. However, the level of salusin-α was not directly associated with the IMT in all the groups. Serum salusin-α levels are increased in RA and BD, although they have increased IMT. Salusin-α has been reported to have anti-atherogenic effects in previous studies. However, it seems that salusin-α does not directly affect the atherogenesis in RA and BD. Further studies are needed to understand the regulation of salusin-α and determination of its relations with the predictors of atherosclerosis in RA and BD. |
| Databáze: | OpenAIRE |
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