The Association of HLA-B8 with Atrophic Thyroiditis
| Autor: | John C. Bear, Hilda Moens, John M. Barnard, Nadir R. Farid |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Thyroiditis
endocrine system endocrine system diseases Immunology Thyroid Gland Human leukocyte antigen Disease Biochemistry Autoimmune Diseases Autoimmune thyroiditis Epitopes Atrophy HLA Antigens Genetics medicine Humans Immunology and Allergy Lymphocytes Goiter business.industry General Medicine medicine.disease Anti-thyroid autoantibodies Atrophic thyroiditis Titer business |
| Zdroj: | Tissue Antigens. 13:342-348 |
| ISSN: | 1399-0039 0001-2815 |
| Popis: | One-hundred-and-forty-seven patients with autoimmune thyroiditis were studied with respect to HLA antigens as they related to various clinical features. HLA--B8 was found to be significantly increased among 59 patients with atrophic thyroiditis (57% vs. 26% for controls) but was identical to controls in 88 patients with goitrous thyroiditis (26%). No relation was found in either group between B8 and thyroid autoantibody titer or, in the case of goitrous thyroiditis, the rate of progression of the disease. Thus a link seems to be established between Graves' disease and atrophic thyroiditis in that both are significantly associated with HLA-B8. This study stresses the need to take clinical features into consideration when examining for HLA/disease associations. |
| Databáze: | OpenAIRE |
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