Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study
| Autor: | Kayla Stratton, Peter D. Inskip, Rita E. Weathers, Marilyn Stovall, Sue Hammond, Sarah S. Donaldson, Gregory T. Armstrong, Leslie L. Robison, Joseph P. Neglia, Houda Boukheris, Susan A. Smith, Ann C. Mertens, Ethel S. Gilbert |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Risk Oncology Cancer Research medicine.medical_specialty Neoplasms Radiation-Induced Adolescent Alcohol Drinking medicine.medical_treatment Population Antineoplastic Agents Childhood Cancer Survivor Study Salivary Glands Article Young Adult Neoplasms Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Cumulative incidence Poisson Distribution Survivors Child education Retrospective Studies education.field_of_study Radiation business.industry Incidence Incidence (epidemiology) Smoking Age Factors Infant Cancer Neoplasms Second Primary Radiotherapy Dosage Salivary Gland Neoplasms medicine.disease Surgery Radiation therapy Salivary gland cancer Child Preschool Relative risk Female business SEER Program |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 85:776-783 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2012.06.006 |
| Popis: | Purpose To evaluate effects of radiation therapy, chemotherapy, cigarette smoking, and alcohol consumption on the risk of second primary salivary gland cancer (SGC) in the Childhood Cancer Survivor Study (CCSS). Methods and Materials Standardized incidence ratios (SIR) and excess absolute risks (EAR) of SGC in the CCSS were calculated using incidence rates from Surveillance, Epidemiology, and End Results population-based cancer registries. Radiation dose to the salivary glands was estimated based on medical records. Poisson regression was used to assess risks with respect to radiation dose, chemotherapy, smoking, and alcohol consumption. Results During the time period of the study, 23 cases of SGC were diagnosed among 14,135 childhood cancer survivors. The mean age at diagnosis of the first primary cancer was 8.3 years, and the mean age at SGC diagnosis was 24.8 years. The incidence of SGC was 39-fold higher in the cohort than in the general population (SIR = 39.4; 95% CI = 25.4-57.8). The EAR was 9.8 per 100,000 person-years. Risk increased linearly with radiation dose (excess relative risk = 0.36/Gy; 95% CI = 0.06-2.5) and remained elevated after 20 years. There was no significant trend of increasing risk with increasing dose of chemotherapeutic agents, pack-years of cigarette smoking, or alcohol intake. Conclusion Although the cumulative incidence of SGC was low, childhood cancer survivors treated with radiation experienced significantly increased risk for at least 2 decades after exposure, and risk was positively associated with radiation dose. Results underscore the importance of long-term follow up of childhood cancer survivors for the development of new malignancies. |
| Databáze: | OpenAIRE |
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