Clinical evaluation of flufenisal, a long-acting analgesic
| Autor: | Thomas P. Barden, Saul S. Bloomfield, R N Ravinna Hille |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Adult
Episiotomy Time Factors Adolescent medicine.medical_treatment Analgesic Pain relief Pain Placebo Placebos Pregnancy Humans Medicine Pharmacology (medical) Pharmacology Analgesics Clinical Trials as Topic Aspirin business.industry Biphenyl Compounds Fluorine Long acting Pain reduction Anesthesia Female Analgesia business Clinical evaluation medicine.drug |
| Zdroj: | Clinical Pharmacology & Therapeutics. 11:747-754 |
| ISSN: | 0009-9236 |
| DOI: | 10.1002/cpt1970115747 |
| Popis: | The analgesic activity of 300 and 600 mg. of flufenisal, a fluorinated phenyl derivative of aspirin, was compared to 600 and 1,200 mg. of aspirin and to placebo under randomized double-blind conditions in 100 patients with pain due to episiotomy. Over the 8 hours of evaluation, pain reduction greater than 50 per cent was observed in at least 60 per cent of patients treated with both doses of flufenisal, whereas it was 40 per cent with 600 mg. of aspirin, 55 per cent with 1,200 mg. of aspirin, and 26 per cent with placebo. On a time-effect basis with the two graded doses of both flufenisal and aspirin, pain relief, as measured by pain intensity differences, was similar with respect to time of onset and maximal effect attained. However, with the flufenisal significant analgesia persisted at the eighth hour (p < 0.02), while with the aspirin there was none after the fifth hour. On the basis of these data, flufenisal at one fourth to one half the dose of aspirin appears to provide analgesia of almost double the duration of aspirin and is equivalent to aspirin in time of onset and degree of relief of episiotomy pain. This raises the possibility that in some clinical conditions flufenisal may be effective in providing prolonged pain relief. |
| Databáze: | OpenAIRE |
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