Role of Pleiotropic Properties of Peroxisome Proliferator-Activated Receptors in the Heart: Focus on the Nonmetabolic Effects in Cardiac Protection
Autor: | Kyriakos Mellidis, Eleftheria Galatou, Tanya Ravingerova, Antigone Lazou, Eleftheria Barlaka |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Cardiac function curve Heart Diseases Peroxisome Proliferator-Activated Receptors Pharmacology medicine.disease_cause Energy homeostasis PPAR agonist 03 medical and health sciences Animals Humans Medicine Pharmacology (medical) Molecular Targeted Therapy Receptor business.industry Myocardium Cardiovascular Agents Lipid metabolism General Medicine medicine.disease 030104 developmental biology Nuclear receptor Drug Design Cardiology and Cardiovascular Medicine business Reperfusion injury Oxidative stress Signal Transduction |
Zdroj: | Cardiovascular Therapeutics. 34:37-48 |
ISSN: | 1755-5914 |
Popis: | Peroxisome proliferator-activated receptors, PPARα, PPARβ/δ, and PPARγ, are a group of nuclear receptors that function as transcriptional regulators of lipid metabolism, energy homeostasis, and inflammation. Given the role of metabolism imbalance under pathological states of the heart, PPARs have emerged as important therapeutic targets, and accumulating evidence highlights their protective role in the improvement of cardiac function under diverse pathological settings. Although the role of PPARs in the regulation of cardiac substrate utilization preference and energy homeostasis is well documented, their effects related to the regulation of cellular inflammatory and redox responses in the heart are less studied. In this review, we provide an overview on recent progress with respect to understanding the role of the nonmetabolic effects of PPARs in cardiac dysfunction, namely during ischemia/reperfusion injury, hypertrophy, and cardiac failure, and highlight the mechanisms underlying the protective effects against inflammation, oxidative stress, and cell death. The role of receptor-independent, nongenomic effects of PPAR agonists is also discussed. |
Databáze: | OpenAIRE |
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