Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies

Autor: Fulvio Ricceri, Joseph A. Rothwell, Amanda J. Cross, Graham G. Giles, Elisabete Weiderpass, Tilman Kühn, Emily Sonestedt, Yi Yang, Rudolf Kaaks, Valeria Pala, Anna Karakatsani, Dallas R. English, Rosario Tumino, Pilar Amiano, Antonia Trichopoulou, John L. Hopper, Leila Lujan-Barroso, Allison M. Hodge, Bengt Wallner, Ruth C. Travis, María Dolores López, Anne Tjønneland, Hazel M. Mitchell, Kostas Tsilidis, Domenico Palli, Harindra Jayasekara, Elio Riboli, Antonio Agudo, Robin Room, Heiner Boeing, Eva Ardanaz, Bas Bueno-de-Mesquita, Torkjel M. Sandanger, Pietro Ferrari, Robert J. MacInnis, Susana Merino, Andrew Haydon, Eleni Peppa, Marie-Christine Boutron-Ruault, Salvatore Panico, María José Sánchez, Marc J. Gunter, Hanna Sternby, Roger L. Milne, Gianluca Severi, Ana Lucia Mayen-Chacon
Přispěvatelé: Centre international de Recherche sur le Cancer (CIRC), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), VicHealth Kræftens Bekæmpelse, DCS German Cancer Research Center, DKFZ Centre International de Recherche sur le Cancer, CIRC Wellcome Trust, WT Medical Research Council, MRC: MC‐UU_12015/1, MR/M012190/1, MR/N003284/1 British Heart Foundation, BHF Department of Health and Social Care, DH Cancer Research UK, CRUK: C570/ A16491, C8221/A19170, C864/A14136 World Cancer Research Fund, WCRF Food Standards Agency, FSA Stroke Association European Commission, EC National Health and Medical Research Council, NHMRC: 1074383, 209057, 396414, GNT1163120 Cancer Council Victoria Institut National de la Santé et de la Recherche Médicale, Inserm Bundesministerium für Bildung und Forschung, BMBF Cancerfonden Ministerie van Volksgezondheid, Welzijn en Sport, VWS Ligue Contre le Cancer Stavros Niarchos Foundation, SNF Vetenskapsrådet, VR Consiglio Nazionale delle Ricerche, CNR Ministère des Affaires Sociales et de la Santé: GR‐IARC‐2003‐09‐12‐01 Instituto de Salud Carlos III, ISCIII Associazione Italiana per la Ricerca sul Cancro, AIRC Deutsche Krebshilfe Rijksinstituut voor Volksgezondheid en Milieu, RIVM Institut Gustave-Roussy Mutuelle Générale de l'Education Nationale, MGEN Ministry of Health and Social Solidarity, Greece Foundation for Alcohol Research and Education, FARE Hellenic Health Foundation, HHF, Australian National Health and Medical Research Council, Grant/Award Numbers: 1074383, 209057, 396414, GNT1163120, Cancer Council Victoria (Australia), Cancer Research UK, Grant/Award Numbers: C570/ A16491, C8221/A19170, C864/A14136, Catalan Institute of Oncology ‐ ICO (Spain), Danish Cancer Society, Deutsche Krebshilfe, the Deutsches Krebsforschungszentrum (Germany), Dutch Ministry of Public Health, Welfare and Sports, European Commission (Directorate General for Health and Consumer Affairs), Foundation for Alcohol Research and Education (Australia), French Ministry of Health, Grant/Award Number: Grant GR‐IARC‐2003‐09‐12‐01, Health Research Fund (FIS) ‐ Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, Hellenic Health Foundation (Greece), Hellenic Ministry of Health and Social Solidarity (Greece), Institut National de la Santé et de la Recherche Médicale (France), Italian Association for Research on Cancer and the National Research Council (Italy), Ligue Contre le Cancer (France), LK Research Funds, Dutch Prevention Funds, the Dutch Zorg Onderzoek Nederland, Medical Research Council (UK), Grant/Award Numbers: MC‐UU_12015/1, MR/M012190/1, MR/N003284/1, Mutuelle Générale de l'Education Nationale, National Institute for Public Health and the Environment (RIVM) (the Netherlands), Netherlands Cancer Registry, Stavros Niarchos Foundation (Greece), Stroke Association, the British Heart Foundation, the Department of Health, the Food Standards Agency and the Wellcome Trust (UK), Swedish Cancer Society, the Swedish Scientific Council and the Regional Government of Skåne (Sweden), the Federal Ministry of Education and Research (Germany), VicHealth (Australia), World Cancer Research Fund and Statistics Netherlands (the Netherlands), the Institut Gustave Roussy Funding information, We thank Carine Biessy and Bertrand Hemon for their technical contribution to EPIC data used in this work. We are also grateful to all the EPIC participants who have been part of the project, and to the many members of the study teams who enabled this research. We thank the original MCCS investigators and the diligent team, who recruited the participants and who continue working on follow‐up, for their contribution. We also express our gratitude to the many thousands of Melbourne residents who continue to participate in the study. This work was supported by the Direction Générale de la Santé (French Ministry of Health, Grant GR‐IARC‐2003‐09‐12‐01), by the European Commission (Directorate General for Health and Consumer Affairs) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Denmark), the Ligue Contre le Cancer, the Institut Gustave Roussy, the Mutuelle Générale de l'Education Nationale and the Institut National de la Santé et de la Recherche Médicale (France), the Deutsche Krebshilfe, the Deutsches Krebsforschungszentrum and the Federal Ministry of Education and Research (Germany), the Hellenic Health Foundation, the Stavros Niarchos Foundation and the Hellenic Ministry of Health and Social Solidarity (Greece), the Italian Association for Research on Cancer and the National Research Council (Italy), the Dutch Ministry of Public Health, Welfare and Sports, the Netherlands Cancer Registry, LK Research Funds, Dutch Prevention Funds, the Dutch Zorg Onderzoek Nederland, the World Cancer Research Fund and Statistics Netherlands (the Netherlands), the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands, for their contribution and ongoing support to the EPIC Study, the Health Research Fund (FIS) ‐ Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology ‐ ICO (Spain), the Swedish Cancer Society, the Swedish Scientific Council and the Regional Government of Skåne (Sweden), Cancer Research UK (C864/A14136 to EPIC‐Norfolk, C570/A16491 and C8221/A19170 to EPIC‐Oxford), Medical Research Council (MR/N003284/1 and MC‐UU_12015/1 to EPIC‐Norfolk, MR/M012190/1 to EPIC‐Oxford, United Kingdom), the Stroke Association, the British Heart Foundation, the Department of Health, the Food Standards Agency and the Wellcome Trust (UK). MCCS cohort recruitment was funded by Cancer Council Victoria ( https://www.cancervic.org.au/ ) and VicHealth ( https://www.vichealth.vic.gov.au/ ). The MCCS was further supported by Australian National Health and Medical Research Council (NHMRC) ( https://www.nhmrc.gov.au/ ) grants 209057, 396414 and 1074383, and ongoing follow‐up and data management has been funded by Cancer Council Victoria since 1995. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database. Harindra Jayasekara is supported by NHMRC grant GNT1163120. John L. Hopper is a NHMRC Senior Principal Research Fellow. Yi Yang is supported by a Melbourne Research Scholarship from the University of Melbourne. Robin Room's position was funded by the Foundation for Alcohol Research and Education. The sponsors had no role in the design and conduct of the study, collection, management, analysis, and interpretation of the data, preparation, review, or approval of the manuscript, and decision to submit the manuscript for publication.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Cancer Research
Gastroenterology
0302 clinical medicine
Prospective Studies
Stomach cancer
Prospective cohort study
stomach cancer
biology
Stomach
Incidence
Hazard ratio
Smoking
cardia cancer
Cardia cancer
Middle Aged
Lifetime alcohol intake
3. Good health
European Prospective Investigation into Cancer and Nutrition
Europe
medicine.anatomical_structure
Oncology
Drinking of alcoholic beverages
030220 oncology & carcinogenesis
Consum d'alcohol
Female
Life Sciences & Biomedicine
Cohort study
Adult
medicine.medical_specialty
Alcohol Drinking
[SDV.CAN]Life Sciences [q-bio]/Cancer
Helicobacter Infections
noncardia cancer
03 medical and health sciences
Stomach Neoplasms
Internal medicine
medicine
Humans
1112 Oncology and Carcinogenesis
Oncology & Carcinogenesis
Aged
Science & Technology
Helicobacter pylori
EPIC
lifetime alcohol intake
MCCS
business.industry
Càncer d'estómac
Kirurgi
Australia
Cancer
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Noncardia cancer
medicine.disease
biology.organism_classification
Surgery
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Zdroj: International Journal of Cancer
International Journal of Cancer, Wiley, 2021, 148 (11), pp.2759-2773. ⟨10.1002/ijc.33504⟩
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Dipòsit Digital de la UB
Universidad de Barcelona
Jayasekara, H, MacInnis, R J, Lujan-Barroso, L, Mayen-Chacon, A-L, Cross, A J, Wallner, B, Palli, D, Ricceri, F, Pala, V, Panico, S, Tumino, R, Kuehn, T, Kaaks, R, Tsilidis, K, Sanchez, M-J, Amiano, P, Ardanaz, E, Chirlaque Lopez, M D, Merino, S, Rothwell, J A, Boutron-Ruault, M-C, Severi, G, Sternby, H, Sonestedt, E, Bueno-de-Mesquita, B, Boeing, H, Travis, R, Sandanger, T M, Trichopoulou, A, Karakatsani, A, Peppa, E, Tjonneland, A, Yang, Y, Hodge, A M, Mitchell, H, Haydon, A, Room, R, Hopper, J L, Weiderpass, E, Gunter, M J, Riboli, E, Giles, G G, Milne, R L, Agudo, A, English, D R & Ferrari, P 2021, ' Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer : A pooled analysis of data from two prospective cohort studies ', International Journal of Cancer, vol. 148, no. 11, pp. 2759-2773 . https://doi.org/10.1002/ijc.33504
Digibug. Repositorio Institucional de la Universidad de Granada
instname
ISSN: 0020-7136
1097-0215
DOI: 10.1002/ijc.33504⟩
Popis: Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.
National Health and Medical Research Council of Australia 1074383 209057 396414 GNT1163120
Canadian Institutes of Health Research (CIHR) Cancer Council Victoria
Cancer Research UK C570/A16491 C8221/A19170 C864/A14136
Catalan Institute of Oncology - ICO (Spain)
Danish Cancer Society
Deutsche Krebshilfe
Deutsches Krebsforschungszentrum (Germany)
Dutch Ministry of Public Health, Welfare and Sports
European Commission European Commission Joint Research Centre
Foundation for Alcohol Research and Education (Australia)
French Ministry of Health GR-IARC-2003-09-12-01
Health Research Fund (FIS) -Instituto de Salud Carlos III (ISCIII)
Junta de Andalucía
Regional Government of Asturias
Basque Government
Regional Government of Murcia
Regional Government of Navarra
Hellenic Health Foundation (Greece)
Hellenic Ministry of Health and Social Solidarity (Greece)
Institut National de la Sante et de la Recherche Medicale (Inserm)
Consiglio Nazionale delle Ricerche (CNR)
Associazione Italiana per la Ricerca sul Cancro (AIRC)
Ligue Contre le Cancer (France)
LK Research Funds
Dutch Prevention Funds
Netherlands Organization for Scientific Research (NWO)
UK Research & Innovation (UKRI) Medical Research Council UK (MRC) MC-UU_12015/1 MR/M012190/1 MR/N003284/
Mutuelle Generale de l'Education Nationale
National Institute for Public Health and the Environment (RIVM) (the Netherlands)
Netherlands Cancer Registry
Stavros Niarchos Foundation (Greece)
Stroke Association (UK)
British Heart Foundation
Department of Health (UK)
Food Standards Agency (UK)
Wellcome Trust
Swedish Cancer Society
Swedish Scientific Council (Sweden)
Regional Government of Skane (Sweden)
Federal Ministry of Education & Research (BMBF)
VicHealth (Australia)
World Cancer Research Fund and Statistics Netherlands (the Netherlands)
Institut Gustave Roussy
Databáze: OpenAIRE
Externí odkaz: