Association of Autoimmune Hepatitis and Celiac Disease: Role of Gluten-Free Diet in Reversing Liver Dysfunction
| Autor: | Nancy Merrell, Umair Iqbal, Muhammad Arsalan Siddiqui, Hafsa Anwar, Muhammad Arsalan Karim, Ahmad Chaudhary |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Budesonide
Epidemiology Bilirubin Azathioprine Case Report Disease Autoimmune hepatitis Serology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine gluten-free diet lcsh:Pathology Medicine Safety Risk Reliability and Quality lcsh:R5-920 gluten-sensitive enteropathy autoimmune hepatitis business.industry medicine.disease digestive system diseases chemistry 030220 oncology & carcinogenesis Immunology Etiology 030211 gastroenterology & hepatology Gluten free business lcsh:Medicine (General) Safety Research celiac disease medicine.drug lcsh:RB1-214 |
| Zdroj: | Journal of Investigative Medicine High Impact Case Reports Journal of Investigative Medicine High Impact Case Reports, Vol 5 (2017) |
| ISSN: | 2324-7096 |
| Popis: | Autoimmune hepatitis (AIH) is a chronic inflammation of liver with unclear etiology. It is frequently associated other autoimmune diseases, and its association with celiac disease (CD) is well established. In this article, we describe the case of a 50-year-old male with long-standing AIH taking azathioprine for 10 years, evaluated for flares in transaminases. Despite adding high-dose corticosteroids, his transaminases and bilirubin remained high. Serology for CD was ordered, which revealed elevated tissue transglutaminase antibody IgG and endomysial IgA, which was further confirmed by endoscopic biopsy. Strict gluten-free diet was advised and now for over 2 years he is in remission with azathioprine and budesonide. This emphasizes the role of gluten-free diet in reversing liver dysfunction in patients with AIH, and clinicians should consider screening for CD in patients with AIH with persistent elevation of liver enzymes despite immunosuppressant treatment. |
| Databáze: | OpenAIRE |
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