Alveolar bone response to submerged bisphosphonate-complexed hydroxyapatite implants
| Autor: | C. Montanari, A. van Lingen, H.W. Denissen, R. Martinetti, A. van den Hooff |
|---|---|
| Přispěvatelé: | Orale Implantologie en Prothetiek (OUD, ACTA) |
| Rok vydání: | 2000 |
| Předmět: |
Bone Regeneration
medicine.medical_treatment Alveolar Bone Loss Dentistry Biocompatible Materials Mandible Absorptiometry Photon Bone Density medicine Alveolar Process Animals Humans Tooth Socket Dental alveolus Dental Implants Drug Carriers Diphosphonates business.industry Chemistry Goats Dental Implantation Endosseous Bisphosphonate Drug Combinations Durapatite Multivariate Analysis Periodontics business |
| Zdroj: | Denissen, H W, Montanari, C, Martinetti, R, van Lingen, A & van den Hooff, A 2000, ' Alveolar bone response to submerged bisphosphonate-complexed hydroxyapatite implants ', Journal of Periodontology, vol. 71, pp. 272-278 . https://doi.org/10.1902/jop.2000.71.2.272 Journal of Periodontology, 71, 272-278. John Wiley & Sons Inc. Journal of Periodontology, 71, 272-278. American Academy of Periodontology |
| ISSN: | 0022-3492 |
| DOI: | 10.1902/jop.2000.71.2.272 |
| Popis: | In most studies using submerged hydroxyapatite implants, maintenance of alveolar bone after tooth extraction was attempted with plain hydroxyapatite materials. However, clinical results have shown that hydroxyapatite may require biological modification with a bone resorption-inhibiting agent which may be beneficial for maintenance of alveolar bone. We conducted experimental and clinical studies to evaluate the effect of highly bisphosphonate-complexed hydroxyapatite implants on osteoconduction and repair in alveolar bone.Porous hydroxyapatite implants were pre-incubated in 10(-2)M bisphosphonate solutions at pH 3.49. The implants had a diameter of 2.1 mm and a height of 2 mm and adsorbed 115 microg bisphosphonate. Five goats were implanted with 4 plain hydroxyapatite implants on each side of the mandible in root extraction sockets for the precision analysis of dual x-ray absorptiometry (DEXA) measurements. Ten goats were implanted with 4 bisphosphonate/hydroxyapatite implants on one side of the mandible and 4 plain hydroxyapatite implants on the opposite mandible. In a clinical study, 23 bisphosphonate/hydroxyapatite implants were placed in periodontally destroyed tooth root sockets and followed up during one year.The range for the bone mineral density (BMD) measurement errors for goat histologic sections was 0.48% to 1.03%. There were large differences in peri-implant BMDs in the left and right mandible of the same goat, irrespective as to whether hydroxyapatite or bisphosphonate/hydroxyapatite implants were present. This was due to local anatomical differences typical of alveolar bone. These differences were not significant. Histologically, all bisphosphonate/hydroxyapatite as well as hydroxyapatite controls appeared to be fully integrated and effective as bone replacement material in goat alveolar bone. They exhibited vascularization and osteoconduction of alveolar bone growth along and inside their porous structure. In patients peri-implant healing was clinically and radiographically comparable to plain hydroxyapatite implants. All implants were retained and no dehiscences developed. Radiographically, peri-implant radiolucencies disappeared and alveolar bone was deposited in close proximity to the implants.This study contributes to the understanding of the biological properties of hydroxyapatite implants as carriers for the bone-modulating agent bisphosphonate. Our study suggests that normal osteoconduction and repair occurred in alveolar bone around the highly bisphosphonate-complexed hydroxyapatite implants. |
| Databáze: | OpenAIRE |
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