Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs

Autor: Matti Waris, Ville Peltola, Maris Rulli, Laura Toivonen, Mohamed Yahya
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Myxovirus Resistance Proteins
viruses
law.invention
0302 clinical medicine
Viral Respiratory Tract Infection
law
Immunology and Allergy
030212 general & internal medicine
Respiratory system
Child
Respiratory Tract Infections
Polymerase chain reaction
respiratory system
3. Good health
tripartite-motif 21
Infectious Diseases
Ribonucleoproteins
Nasal Swab
Virus Diseases
Viperin
Child
Preschool
Viruses
Host-Pathogen Interactions
biomarker
Female
medicine.symptom
viperin
Oxidoreductases Acting on CH-CH Group Donors
Adolescent
ta3111
Asymptomatic
Virus
03 medical and health sciences
Major Articles and Brief Reports
respiratory viruses
medicine
otorhinolaryngologic diseases
Humans
myxovirus resistance protein A
RNA
Messenger
Messenger RNA
business.industry
Infant
Newborn
Infant
Proteins
Virology
ta3123
030104 developmental biology
Immunology
business
Biomarkers
Zdroj: The Journal of Infectious Diseases
ISSN: 0022-1899
DOI: 10.1093/infdis/jix458
Popis: We found nasal myxovirus resistance protein A and viperin messenger RNA indexes to be promising biomarkers of respiratory virus infection in children. These host response markers can be measured in the same nasal swabs that are used for virus detection.
Respiratory viruses frequently cause symptomatic infections in children but are often detected also in healthy children. We investigated myxovirus resistance protein A (MxA), viperin, and tripartite-motif 21 (TRIM21) messenger RNA indexes in nasal swabs as potential biomarkers of viral respiratory infection in children. Respiratory viruses were detected by polymerase chain reaction in the same swabs. Nasal MxA and viperin indexes were increased in symptomatic virus-positive children. Nasal viperin index was found to be a robust marker of viral respiratory tract infection with a sensitivity of 80% and specificity of 94% in distinguishing children with symptomatic virus infections from asymptomatic virus-negative children.
Databáze: OpenAIRE
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