Experimental Production of Elevated Serum Folate in Dogs with Intestinal Blind Loops: Relationship of Serum Levels to Location of the Blind Loop
| Autor: | Gael Wager, Gershon Efron, Sidney Gutstein, Leslie H. Bernstein |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
medicine.medical_specialty
Lactobacillus casei Ileum Biology medicine.disease_cause Jejunum Elevated serum Ileocecal valve Dogs Folic Acid Internal medicine Enterococcus faecalis medicine Animals Serum folate level Hepatology Streptococcus digestive oral and skin physiology Gastroenterology biology.organism_classification Loop (topology) Intestinal Diseases Lacticaseibacillus casei Endocrinology medicine.anatomical_structure Biological Assay Blind Loop Syndrome |
| Zdroj: | Gastroenterology. 63:815-819 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/s0016-5085(19)33222-6 |
| Popis: | The serum folate level in dogs with intestinal blind loops was studied. Twenty dogs were divided into five equal groups. In group I, a self-filling blind loop was constructed at the ligament of Treitz. In group II, a similar blind loop was made at the ileocecal valve. Group III dogs had a self-filling blind loop constructed at the ligament of Treitz by transposing a segment of ileum. In group IV, jejunum was transposed to the ileocecal valve. Group V dogs had both high and low self-emptying blind loops and served as control animals. Each blind loop was 18 inches long. In those dogs with high blind loops (groups I and III) serum folate, as measured by Lactobacillus casei, rose to a mean height of 45 ng per ml in 3 to 9 weeks. Dogs with a low blind loop of transposed jejunum (group IV) showed an intermediate rise in serum folate to a mean of 16 ng per ml, while those with a low ileal blind loop (group II) showed no rise at all. In dogs with a self- emptying blind loop (group V) serum folate remained within the normal range—4 to 8 ng per ml. Elevated serum folate occurred with L. casei as the assay organism but not when Streptococcus faecalis was used. This suggests that the elevated serum folate is 5-methyltetrahydrofolate. The failure of L. casei active serum folate to rise in dogs with a low ileal blind loop despite an extremely high folate content of loop fluid suggests that the ileum in dogs is unable to absorb folates. |
| Databáze: | OpenAIRE |
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