Retention of Ingested Latex Particles in Peyer's Patches of Germfree and Conventional Mice

Autor:	M. E. LeFevre, G. Schidlovsky, Darrel D. Joel
Rok vydání:	1985
Předmět:	Hydrogen compounds Latex Germ-free animal Biological Transport Biology General Biochemistry Genetics and Molecular Biology Microbiology Peyer Patch Mice Peyer's Patches Lymphatic system Animals Germ-Free Life Particle Female Tissue distribution Clearance
Zdroj:	Experimental Biology and Medicine. 179:522-528
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-179-42133
Popis:	Conventional and germ-free mice ingested a suspension of 2-..mu..m latex particles in drinking water for a 15-day period. Number and distribution of intestinal Peyer's patches did not differ significantly in the two types of mice. Cleared Peyer's patches were compared with regard to size and particle content. The location of particles within Peyer's patch follicles of germ-free mice was similar to that of conventional mice, but the latter had significantly larger follicles and greater accumulations of latex particles. Latex concentration varied with patch location. Proximal patches contained the majority of particles in germ-free mice, whereas particles were most abundant in distal patches of conventional mice. The results show that particle uptake into Peyer's patches takes place even in the complete absence of bacteria in the gut.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a300e3dc54aae20e08be7d6c88ab8c2a https://doi.org/10.3181/00379727-179-42133 Zobrazit plný text záznamu