Vaccination against Fasciola hepatica infection using a Schistosoma mansoni defined recombinant antigen, Sm14
| Autor: | Andrew J. G. Simpson, Miriam Tendler, Humberto Torloni, Mônica Magno Vilar, Paulo Lee‐Ho, Nilton Thaumaturgo, Marilia S. Almeida |
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| Rok vydání: | 2003 |
| Předmět: |
Fascioliasis
Immunology law.invention law Hepatica parasitic diseases medicine Animals Infection control Fasciola hepatica Fasciolosis Vaccines Synthetic Sheep biology Transmission (medicine) Vaccination Membrane Transport Proteins Helminth Proteins Schistosoma mansoni Fatty Acid Transport Proteins biology.organism_classification medicine.disease Virology Recombinant Proteins Immunity Active Liver Antigens Helminth Recombinant DNA Parasitology Carrier Proteins |
| Zdroj: | Parasite Immunology. 25:135-137 |
| ISSN: | 1365-3024 0141-9838 |
| DOI: | 10.1046/j.1365-3024.2003.00619.x |
| Popis: | SUMMARY Fasciola hepatica is the causative agent of fasciolosis in manyareas in America, Europe, Africa, Asia and Australia. Thereis an urgent need for improved methods to control the para-site’s transmission. We describe the use of an experimentalvaccine based on a recombinant antigen cloned from anotherparasite, Schistosoma mansoni (Sm14), that induces highlevels of cross protection in mice against both S. mansoni andF. hepatica. Sheep and mice vaccinated with Sm14 weresignificantly protected against challenge infection with meta-cercariae of Fasciola hepatica and were completely free of thehistopathological hepatic damage related to liver fluke infec-tion. The vaccine will provide a valuable new tool to aid intransmission control of this economically important disease.Keywords FABP, Fasciola hepatica, histopathology, sheep,vaccine RESEARCH NOTE Fasciolosis is a major disease of ruminants worldwide,which is responsible for the infection of estimated 300 000head of cattle in endemic countries and annual losses ofabout US$3 000 000 (1). Despite the availability of specificchemotherapy, cost of repeated treatment, drug-resistanceand the presence of chemical residues in food, point to aclear demand for the development of effective vaccines, asalternative methods for infection control (2–5).Previous studies directed originally toward the develop-ment of a |
| Databáze: | OpenAIRE |
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