Dynamics of polyelectrolyte transport through a protein channel as a function of applied voltage
| Autor: | Juan Pelta, Laurent Bacri, G. Oukhaled, Ludovic Brun, Loïc Auvray, Manuela Pastoriza-Gallego, Jérôme Mathé |
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| Přispěvatelé: | Institut de Chimie et des Matériaux Paris-Est (ICMPE), Institut de Chimie du CNRS (INC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement (LAMBE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2007 |
| Předmět: |
Materials science
Entropy Lipid Bilayers General Physics and Astronomy DNA Single-Stranded Nanotechnology 02 engineering and technology 01 natural sciences Effective nuclear charge Hemolysin Proteins Electric field 0103 physical sciences Electrochemistry 010306 general physics Ion channel Dynamics (mechanics) Dextran Sulfate Osmolar Concentration Function (mathematics) 021001 nanoscience & nanotechnology Polyelectrolyte Exponential function Chemical physics 0210 nano-technology [PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft] Voltage |
| Zdroj: | Physical Review Letters Physical Review Letters, 2008, 100 (15), pp.158302. ⟨10.1103/PhysRevLett.100.158302⟩ Physical Review Letters, American Physical Society, 2008, 100 (15), pp.158302. ⟨10.1103/PhysRevLett.100.158302⟩ |
| ISSN: | 0031-9007 1079-7114 |
| DOI: | 10.1103/PhysRevLett.100.158302⟩ |
| Popis: | International audience; We study the transport of dextran sulfate through a protein channel as a function of applied voltage. Below 60 mV, the chain’s entrance to the pore is hindered by an entropic barrier; above 60 mV, the strong local electric field forces the chain entrance. The effective charge of the polyelectrolyte inside the pore is reduced. We observe two types of blockades which have durations that decrease when the applied voltage increases. The shortest is a straddling time between the polyelectrolyte and the pore; the longest is the translocation time. The translocation time obeys an exponential dependence upon applied voltage. |
| Databáze: | OpenAIRE |
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