Protein Expression Level of Skin Wrinkle-Related Factors in Hairless Mice Fed Hyaluronic Acid
| Autor: | Hye-Jin Song, Johann Sohn, Soo Young Choe, Min-Kyu Yun, Heui-Jong Yu, Chan-Su Rha, Sung-Jin Lee, Dae-Ok Kim |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Proteome Ultraviolet Rays Photoaging Administration Oral Medicine (miscellaneous) Enzyme-Linked Immunosorbent Assay Matrix metalloproteinase Protein expression Transforming Growth Factor beta1 Mice 03 medical and health sciences chemistry.chemical_compound In vivo Internal medicine Matrix Metalloproteinase 13 Hyaluronic acid medicine Animals Hyaluronic Acid Wrinkle Skin Mice Hairless Nutrition and Dietetics integumentary system Interleukin-6 Chemistry Interleukin medicine.disease Skin Aging Hairless 030104 developmental biology Endocrinology Biochemistry Female Collagen medicine.symptom |
| Zdroj: | Journal of Medicinal Food. 20:420-424 |
| ISSN: | 1557-7600 1096-620X |
| Popis: | The aim of this study was to evaluate the wrinkle improving effect of hyaluronic acid intakes. Wrinkles were induced by exposing the skin of hairless mice to ultraviolet B (UVB) irradiation for 14 weeks. Hyaluronic acid was administered to the mice for 14 weeks including 4 weeks before experiments. Skin tissue was assayed by enzyme-linked immunosorbent assay to determine protein expression of wrinkle-related markers. The group supplemented with high concentrations of hyaluronic acid appeared significantly better than control group for collagen, matrix metalloproteinase 1, interleukin (IL)-1β, and IL-6 assay. Transforming growth factor-β1 (TGF-β1) and hyaluronic acid synthase 2 (HAS-2) were not shown to be significantly different. In conclusion, hyaluronic acid administration regulated expression levels of proteins associated with skin integrity, and improved the wrinkle level in skin subjected to UVB irradiation. |
| Databáze: | OpenAIRE |
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