Compatibility of different polymers for cord blood-derived hematopoietic progenitor cells
| Autor: | Ruth Knüchel, Mónica S. Ventura Ferreira, Thomas Hieronymus, Daniela Piroth, Norina Labude, Sabine Neuss, Willi Jahnen-Dechent, Martin Zenke |
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| Rok vydání: | 2011 |
| Předmět: |
Materials science
Polymers Biomedical Engineering Biophysics CD34 Antigens CD34 Apoptosis Biocompatible Materials Bioengineering Fetal Blood Hematopoietic Stem Cells Regenerative medicine Cell biology Biomaterials chemistry.chemical_compound Tissue culture chemistry Cord blood Hyaluronic acid Humans Viability assay Progenitor cell Cytotoxicity Cell Proliferation Biomedical engineering |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 23:109-116 |
| ISSN: | 1573-4838 0957-4530 |
| DOI: | 10.1007/s10856-011-4483-4 |
| Popis: | The low yield of hematopoietic progenitor cells (HPC) present in cord blood grafts limits their application in clinics. A reliable strategy for ex vivo expansion of functional HPC is a present goal in regenerative medicine. Here we evaluate the capacity of several two-dimensional polymers to support HPC proliferation. Basic compatibility was tested by measuring cell viability, cytotoxicity and apoptosis of CD34(+) progenitors that were short and long-term exposed to sixteen bio and synthetic polymers. Resomer(®) RG503, PCL and Fibrin might be good alternatives to tissue culture plastic for culture of CB-derived CD34(+) progenitors. Further, these polymers will be produced in three-dimensional structures and tested for their cytocompatibility. |
| Databáze: | OpenAIRE |
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