Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development
| Autor: | Philip A. Robinson, J.P. Leek, Alexander F. Markham, Jimi Adu, Alan J. Mighell, Fong T Leong, Neil R. Smith |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Embryology
medicine.medical_specialty animal structures Molecular Sequence Data Hindbrain Biology Mice Internal medicine Genetics medicine Animals Amino Acid Sequence Amino Acids Molecular Biology Peptide sequence Endocardium Homeodomain Proteins Sinus venosus Base Sequence Gene Expression Profiling Myocardium Genes Homeobox Gene Expression Regulation Developmental Skeletal muscle Heart Sequence Analysis DNA Epithelium Cell biology Endocrinology medicine.anatomical_structure embryonic structures Respiratory epithelium Homeobox Sequence Alignment Developmental Biology |
| Zdroj: | Mechanisms of Development. 119:S43-S47 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/s0925-4773(03)00090-x |
| Popis: | We report the initial characterization of mOb1 (Odd homeoBox 1), which encodes an atypical 73 amino acid K50-homeodomain protein localised in the cytoplasm and absent from nuclei during mouse development. Conserved orthologues were present in man, rat, cow, pig and chicken, but not in fish, amphibians or invertebrates. Temporo-spatial patterns of mOb1 transcript and mOb1 protein expression were coincident in developing mouse embryos. Cardiac expression was first observed at E8.25 in linear heart tube myocardium and briefly in both horns of the sinus venosus. Myocardial expression peaked at E13.5, where after it diminished and was not detectable above background by adulthood. At no stage was expression observed in endocardium, endocardial cushion tissue, the coronary arteries or great vessels. At E13.5 and E15.5, mOb1 expression broadened to include skeletal muscle, stratified epithelium (upper aerodigestive tract and skin), epithelium of developing airways, vibrissae, midbrain/hindbrain junction, meninges, mesenchymal cellular condensations that preceded cartilage formation and chondrocytes. |
| Databáze: | OpenAIRE |
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