Epidermal growth factor requirement for development of cultured mammary gland
| Autor: | Quentin J. Tonelli, Sam Sorof |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Cellular differentiation Mammary gland Biology Organ culture Mice Tissue culture Mammary Glands Animal Organ Culture Techniques Epidermal growth factor In vivo Internal medicine medicine Animals Multidisciplinary Epidermal Growth Factor Cell Differentiation Hormones In vitro Culture Media Cell biology Endocrinology medicine.anatomical_structure Female Peptides Hormone |
| Zdroj: | Nature. 285:250-252 |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | The mouse mammary gland in serum-free whole organ culture can be manipulated hormonally to undergo one complete physiological cycle consisting of lobuloalveolar development, functional differentiation and regression, mimicking processes that occur in vivo. A second cycle has not previously been achieved in vitro. The present study has identified a specific requirement for epidermal growth factor (EGF) in the morphological development of mammary lobuloalveoli, allowing two complete cycles of development and regression in culture. |
| Databáze: | OpenAIRE |
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