Increased eosinophil activity in acutePlasmodium falciparuminfection—association with cerebral malaria
| Autor: | Lars Hviid, Samuel K. Dunyo, Francis K. Nkrumah, Bartholomew D. Akanmori, Edem M. A. Tette, C M Reimert, Jørgen A. L. Kurtzhals, Kwadwo A. Koram |
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| Rok vydání: | 1998 |
| Předmět: |
Plasmodium falciparum
Immunology Malaria Cerebral Enzyme-Linked Immunosorbent Assay Eosinophil-Derived Neurotoxin Cohort Studies Ribonucleases parasitic diseases Eosinophil activation medicine Animals Humans Immunology and Allergy Eosinophilia Longitudinal Studies Child Eosinophil cationic protein biology Eosinophil Granule Proteins Blood Proteins Original Articles Eosinophil biology.organism_classification medicine.disease Eosinophils medicine.anatomical_structure Cerebral Malaria Inflammation Mediators Interleukin-5 medicine.symptom Biomarkers Malaria |
| Zdroj: | Clinical and Experimental Immunology. 112:303-307 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1046/j.1365-2249.1998.00586.x |
| Popis: | SUMMARYTo assess the eosinophil response to Plasmodium falciparum infection a cohort of initially parasite-free Ghanaian children was followed for 3 months. Seven of nine children who acquired an asymptomatic P. falciparum infection showed increase in eosinophil counts, while a decrease was found in seven of nine children with symptomatic malaria, and no change was observed in 14 children who remained parasite-free. In a hospital-based study, paediatric patients with cerebral malaria (CM), severe anaemia (SA), or uncomplicated malaria (UM) had uniformly low eosinophil counts during the acute illness followed by eosinophilia 30 days after cure. Plasma levels of eosinophil cationic protein (ECP) and eosinophil protein X (EPX) were measured as indicators of eosinophil activation. In spite of the low eosinophil counts, ECP levels were increased on day 0 and significantly higher in patients with CM (geometric mean (95% confidence interval) 8·5 ng/ml (6·8–10·7 ng/ml)) than in SA (4·7 ng/ml (3·0–7·5 ng/ml)) and UM patients (4·3 ng/ml (3·6–5·3 ng/ml), P |
| Databáze: | OpenAIRE |
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