Continuous theta burst stimulation over right pars triangularis facilitates naming abilities in chronic post-stroke aphasia by enhancing phonological access
| Autor: | Denise Y. Harvey, Roy H. Hamilton, Laura DeLoretta, Olufunsho Faseyitan, Joely A. Mass, Priyanka P. Shah-Basak, Daniela Sacchetti, Rachel Wurzman |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Linguistics and Language medicine.medical_specialty Cognitive Neuroscience medicine.medical_treatment CTBS Experimental and Cognitive Psychology Stimulation Audiology behavioral disciplines and activities 050105 experimental psychology Language and Linguistics Lateralization of brain function Article 03 medical and health sciences Speech and Hearing 0302 clinical medicine Aphasia medicine Humans 0501 psychology and cognitive sciences Theta Rhythm Stroke Neurorehabilitation 05 social sciences Stroke Rehabilitation Middle Aged medicine.disease Transcranial Magnetic Stimulation Broca Area Semantics Theta burst Transcranial magnetic stimulation Female medicine.symptom Psychology 030217 neurology & neurosurgery |
| Zdroj: | Brain Lang |
| ISSN: | 1090-2155 |
| Popis: | Background Repetitive transcranial magnetic stimulation (rTMS) has been used experimentally to facilitate naming abilities in individuals with chronic post-stroke aphasia. However, little is known about how rTMS confers clinical improvement, hampering its therapeutic value. The present study investigated the characteristics of naming failure that improve following administration of continuous theta burst stimulation (cTBS)—an inhibitory form of rTMS—to the right pars triangularis (rPTr) in persons with chronic aphasia. Methods Eleven participants with chronic aphasia following left hemisphere stroke named pictures prior to and immediately following cTBS of the rPTr and a control site (vertex) in separate sessions. Prior to stimulation, we obtained two baseline measurements of picture naming ability to determine the extent and type (i.e., phonological vs. semantic) of naming impairment. Items presented for naming during stimulation were those that were named incorrectly in one or both of the baseline sessions (i.e., inconsistent vs. wrong items, respectively). Analyses assessed whether cTBS effects differed depending on the severity and/or type of naming impairment. Results Relative to vertex, cTBS of the rPTr improved naming of inconsistent, but not wrong, items for individuals with more severe baseline naming impairment. Critically, baseline phonological but not semantic naming impairment severity marginally correlated with improved accuracy overall, and significantly correlated with decreased phonological errors following rPTr stimulation. Conclusion CTBS of the rPTr enhances naming by facilitating phonological access during word retrieval, indicating that individuals whose naming impairment is localized to this stage of processing may be most likely to benefit from this rTMS approach. |
| Databáze: | OpenAIRE |
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