Biphasic solitary fibrous tumour: a report of two cases with epithelioid features
| Autor: | Vikram S. Devaraj, P. Sarsfield, Christopher Stone, R. Awasthi, C. E. Keen, Mark E F Smith, J. K. O'Neill |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pathology medicine.medical_specialty CD34 Soft Tissue Neoplasms Biology Haematoxylin Pathology and Forensic Medicine Diagnosis Differential Sarcoma Synovial Cytokeratin chemistry.chemical_compound Immunophenotyping Biomarkers Tumor medicine Humans Molecular Biology In Situ Hybridization Fluorescence Cadherin Epithelioid Cells DNA Neoplasm Cell Biology General Medicine Anatomy Middle Aged medicine.disease Synovial sarcoma Cell Transformation Neoplastic chemistry Solitary Fibrous Tumors Immunohistochemistry Female Sarcoma |
| Zdroj: | Virchows Archiv. 448:306-310 |
| ISSN: | 1432-2307 0945-6317 |
| Popis: | We present two cases of solitary fibrous tumour (SFT) showing biphasic morphology with a spectrum of malignant epithelioid components. Slides prepared from formalin-fixed and paraffin-embedded tissue from both cases were stained with haematoxylin and eosin and by immunohistochemistry. Interphase fluorescent in situ hybridisation studies were performed in both cases using paraffin-embedded tissue to look for the t(X;18) translocation, thereby to exclude synovial sarcoma. Both cases showed biphasic morphology with some areas having typical benign spindled SFT morphology (including CD34 expression) and other areas having a malignant epithelioid appearance. In one of the cases, the epithelioid area, which was well circumscribed and showed packeting of cell groups, demonstrated expression of cytokeratin and epithelial cadherin but not of CD34. In the second case, the immunophenotype of the epithelioid component was similar to that of the benign SFT component. These findings suggest that epithelioid change in SFT shows a range of differentiation at one end, similar to that of a standard SFT, and at the other end, possibly acquiring epithelial characteristics. |
| Databáze: | OpenAIRE |
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