Longitudinal assessment of lipoprotein(A) levels in perinatally HIV-infected children and adolescents
| Autor: | Sotirios Tsimikas, Claudia G. de Boer, John J.P. Kastelein, Sander J. H. van Deventer, Hans Jansen, Jason G. van Genderen, Dasja Pajkrt, Malon Van den Hof, Joseph L. Witztum |
|---|---|
| Přispěvatelé: | Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, Vascular Medicine, AII - Infectious diseases, Amsterdam Reproduction & Development (AR&D), APH - Methodology, APH - Societal Participation & Health, APH - Aging & Later Life, ACS - Pulmonary hypertension & thrombosis, ACS - Atherosclerosis & ischemic syndromes |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Apolipoproteins dyslipidemia Human immunodeficiency virus (HIV) HIV Infections Disease Cardiovascular medicine.disease_cause Cohort Studies Risk Factors cardiovascular disease Hiv infected Ethnicity Medicine Outpatient clinic Longitudinal Studies Aetiology Child Pediatric education.field_of_study human immunodeficiency virus biology Human immunodeficiency virus virus diseases atherosclerotic cardiovascular disease Lipoprotein(a) Cardiovascular disease QR1-502 Heart Disease Infectious Diseases Cardiovascular Diseases Child Preschool HIV/AIDS Female Pediatric Research Initiative medicine.medical_specialty Adolescent apolipoproteins dyslipidemia Population Microbiology Article Young Adult Clinical Research Virology Internal medicine Humans cardiovascular diseases Risk factor Preschool education Dyslipidemias business.industry Prevention HIV Atherosclerosis Good Health and Well Being Atherosclerotic cardiovascular disease biology.protein business 2.4 Surveillance and distribution Lipoprotein |
| Zdroj: | Viruses, vol 13, iss 10 Viruses Viruses, 13(10). MDPI Viruses, Vol 13, Iss 2067, p 2067 (2021) Viruses, 13(10):2067. Multidisciplinary Digital Publishing Institute (MDPI) Volume 13 Issue 10 |
| ISSN: | 1999-4915 |
| Popis: | HIV is an independent risk factor of cardiovascular disease (CVD) therefore, perinatally HIV-infected (PHIV) children potentially have a greater CVD risk at older age. Lipoprotein(a) (Lp(a)) is an established risk factor for CVD in the general population. To evaluate a potential increased CVD risk for PHIV children, we determined their lipid profiles including Lp(a). In the first substudy, we assessed the lipid profiles of 36 PHIV children visiting the outpatient clinic in Amsterdam between 2012 and 2020. In the second substudy, we enrolled 21 PHIV adolescents and 23 controls matched for age, sex and ethnic background on two occasions with a mean follow-up time of 4.6 years. We assessed trends of lipid profiles and their determinants, including patient and disease characteristics, using mixed models. In the first substudy, the majority of PHIV children were Black (92%) with a median age of 8.0y (5.7–10.8) at first assessment. Persistent elevated Lp(a) levels were present in 21/36 (58%) children (median: 374 mg/L (209–747) cut off = 300). In the second substudy, the median age of PHIV adolescents was 17.5y (15.5–20.7) and of matched controls 16.4y (15.8–19.5) at the second assessment. We found comparable lipid profiles between groups. In both studies, increases in LDL-cholesterol and total cholesterol were associated with higher Lp(a) levels. A majority of PHIV children and adolescents exhibited elevated Lp(a) levels, probably associated with ethnic background. Nonetheless, these elevated Lp(a) levels may additionally contribute to an increased CVD risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|