Receptive field estimation in large visual neuron assemblies using a super-resolution approach

Autor: Daniela Pamplona, Gerrit Hilgen, Matthias H. Hennig, Bruno Cessac, Evelyne Sernagor, Pierre Kornprobst
Přispěvatelé: Biologically plausible Integrative mOdels of the Visual system : towards synergIstic Solutions for visually-Impaired people and artificial visiON (BIOVISION), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Unité d'Informatique et d'Ingénierie des Systèmes (U2IS), École Nationale Supérieure de Techniques Avancées (ENSTA Paris), Biosciences Institute, Faculty of Medical Sciences [Newcastle], Newcastle University [Newcastle], Department of Applied Sciences, University of Northumbria at Newcastle [United Kingdom], Institute for Adaptive and Neural Computation (ANC), University of Edinburgh, European Project: 600847,EC:FP7:ICT,FP7-ICT-2011-9,RENVISION(2013)
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Pamplona, D, Hilgen, G, Hennig, M H, Cessac, B, Sernagor, E & Kornprobst, P 2022, ' Receptive field estimation in large visual neuron assemblies using a super-resolution approach ', Journal of Neurophysiology, vol. 127, no. 5, pp. 1334-1347 . https://doi.org/10.1152/jn.00076.2021
Journal of Neurophysiology
Journal of Neurophysiology, 2022, 127 (5), pp.1334--1347. ⟨10.1152/jn.00076.2021⟩
ISSN: 0022-3077
1522-1598
Popis: Computing the spike-triggered average (STA) is a simple method to estimate linear receptive fields (RFs) in sensory neurons. For random, uncorrelated stimuli, the STA provides an unbiased RF estimate, but in practice, white noise at high resolution is not an optimal stimulus choice as it usually evokes only weak responses. Therefore, for a visual stimulus, images of randomly modulated blocks of pixels are often used. This solution naturally limits the resolution at which an RF can be measured. Here, we present a simple super-resolution technique that can overcome these limitations. We define a novel stimulus type, the shifted white noise (SWN), by introducing random spatial shifts in the usual stimulus to increase the resolution of the measurements. In simulated data, we show that the average error using the SWN was 1.7 times smaller than when using the classical stimulus, with successful mapping of 2.3 times more neurons, covering a broader range of RF sizes. Moreover, successful RF mapping was achieved with brief recordings of light responses, lasting only about 1 min of activity, which is more than 10 times more efficient than the classical white noise stimulus. In recordings from mouse retinal ganglion cells with large scale multielectrode arrays, we successfully mapped 21 times more RFs than when using the traditional white noise stimuli. In summary, randomly shifting the usual white noise stimulus significantly improves RFs estimation, and requires only short recordings.NEW & NOTEWORTHY We present a novel approach to measure receptive fields in large and heterogeneous populations of sensory neurons recorded with large-scale, high-density multielectrode arrays. Our approach leverages super-resolution principles to improve the yield of the spike-triggered average method. By simply designing a new stimulus, we provide experimentalists with a new and fast technique to simultaneously detect more receptive fields at higher resolution in population of hundreds to thousands of neurons.
Databáze: OpenAIRE
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