Time trends in case selection, stage and prostate-specific antigen recurrence after radical prostatectomy: a multicentre audit
| Autor: | Amir V. Kaisary, David Gillatt, M.H. Winkler, Rajendra Persad, F.A. Khan, IM Hoh, P. McInerney, G.B. Boustead, M. Sugiono, A.A. Okeke |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Biopsy Urology medicine.medical_treatment Adenocarcinoma urologic and male genital diseases Preoperative care Prostate cancer Prostate Preoperative Care Humans Medicine Prospective Studies Stage (cooking) Survival analysis Neoplasm Staging Prostatectomy Medical Audit business.industry Prostatic Neoplasms Middle Aged Prostate-Specific Antigen medicine.disease Survival Analysis Surgery Prostate-specific antigen medicine.anatomical_structure Prostate neoplasm Neoplasm Recurrence Local business |
| Zdroj: | BJU International. 93:725-729 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1111/j.1464-410x.2003.04715.x |
| Popis: | OBJECTIVES To report an audit of preoperative staging variables, case selection, stage migration and prostate-specific antigen (PSA) recurrence at five large centres in the south of England. To establish PSA outcome values after radical prostatectomy for clinically localized prostate cancer in the UK, and enable appropriate patient counselling. PATIENTS AND METHODS The notes of 854 patients were audited for preoperative staging variables and follow-up data obtained. Patients with neoadjuvant and adjuvant treatment, and with incomplete data and follow-up, were excluded. RESULTS The median follow-up was 52 months for the remaining 663 patients; the median PSA level was 10 ng/mL. There was a large migration towards lower PSA and stage; this translated into improved PSA survival rates. The overall Kaplan-Meier PSA recurrence-free survival probability at 1, 3, 5 and 8 years was 0.83, 0.69, 0.60 and 0.48, respectively. The 5-year PSA recurrence-free survival probabilities for PSA levels of 20 ng/mL were 0.82, 0.73, 0.59 and 0.20, respectively (Wilcoxon, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|