| Autor: |
Aneta Czaplinska, Aimee L. Desaki, Maureen P. Howell, Bryan I. Smith, Kevin S. Brockway, Ben J. Duncan, Annabel R. Laramee, Shanna R. Fischer, Tsuey-Ming Chen, Reena Kawal, Nancy Ao, Agnes J. Liang, Amy Bernard, Casey Faber, Ed S. Lein, Geralyn J. Orta, Kevin R. Halverson, Jennifer G. Dougherty, Chinh Dang, Cliff Frensley, Caroline C. Overly, Judith J. Morgan, Murat B. Yaylaoglu, Mark S. Boguski, Lee R. Varnam, Susan M. Sunkin, Crissa K. Wolkey, Amanda Ebbert, Matthew J.A. Wood, Paul Wohnoutka, Benjamin A.C. Facer, Li Chen, Jesse Michaels, James H. Lake, Carey D. Teemer, Rebecca A. Johnson, Axel Visel, Marty Mortrud, Michael Hawrylycz, Christina Thaller, Nerick Mosqueda, Victoria Y. Wong, Tim A. Dolbeare, Xu Feng Yuan, Mei Chi Chin, Marcos J. Ruiz, Carol L. Thompson, Katherine Schaffnit, Theresa A. Zwingman, Sayan Dev Pathak, Tracy Lemon, Lydia Ng, Jimmy Chong, Lili K. Estin, Simon Smith, Rob Young, Kirk D. Larsen, Joshua J. Royall, Randy Ng, Rachel H. Knapik, Mikael Ayres, Nick Dee, Sheana Parry, Ray M. Whitlock, Kenda-Ruth Stumpf, Nadiya V. Shapovalova, Emi J. Byrnes, Taz Sivisay, Matthew R. Hart, Chihchau L. Kuan, Owen C. Pearson, Ellen Diep, Nadia R. Sarno, Madhavi Sutram, Andrew F. Boe, Clifford R. Slaughterbeck, Zackery L. Riley, Rebecca J. Morgan, Hong-Wei Dong, Tsega Desta, Patrick T. Karr, Andy J. Sodt, John G. Hohmann, Suvro Datta, Stephen A. Rowland, Tu H. Pak, Ralph B. Puchalski, Lin Chen, Nick N. Stewart, Ying Liu, Hannah R. Rockett, Brian L. Youngstrom, Darren P. Jeung, Lon T. Luong, Matthew J. Donelan, Amy Bensinger, Katie J. Glattfelder, Bin Zhang, Allan R. Jones, Gregor Eichele, Rick Fields, Sabrina N. Gates, Kimberly A. Smith, Angelene Tam, Brian E. Crook, Tim P. Fliss, Jolene Kidney, Christopher Lau |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Nature. 445:168-176 |
| ISSN: |
1476-4687
0028-0836 |
| DOI: |
10.1038/nature05453 |
| Popis: |
Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We describe here an anatomically comprehensive digital atlas containing the expression patterns of approximately 20,000 genes in the adult mouse brain. Data were generated using automated high-throughput procedures for in situ hybridization and data acquisition, and are publicly accessible online. Newly developed image-based informatics tools allow global genome-scale structural analysis and cross-correlation, as well as identification of regionally enriched genes. Unbiased fine-resolution analysis has identified highly specific cellular markers as well as extensive evidence of cellular heterogeneity not evident in classical neuroanatomical atlases. This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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